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Record W4308010943 · doi:10.21203/rs.3.rs-2097712/v1

Simulations of genomic selection accuracy and model updating across multiple breeding strategy scenarios in common bean

2022· preprint· en· W4308010943 on OpenAlexaff
Isabella Chiaravalotti, Jennifer Lin, Vivi N. Arief, Zulfi Jahufer, Juan M. Osorno, Phillip E. McClean, Diego Jarquín, Valerio Hoyos‐Villegas

Bibliographic record

VenueResearch Square · 2022
Typepreprint
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetic and phenotypic traits in livestock
Canadian institutionsMcGill University
Fundersnot available
KeywordsGenomic selectionSelection (genetic algorithm)Model selectionComputer scienceBiologyMachine learningGeneticsGenotype

Abstract

fetched live from OpenAlex

Abstract Genomic selection predicts the breeding value of selection candidates according to genotypes that are estimated to have favorable effects based on a model. The effectiveness of genomic selection is strongly tied to its prediction accuracy. Previous studies have evaluated the accuracy of genomic selection using simulations. The aim of this study was to evaluate changes in accuracy of genomic selection based on many known QTLs identified in the literature and determine their relationship with true breeding values. Simulation results revealed that correlation-based prediction accuracies (also referred to as realized accuracy) fluctuate depending on trait genetic architecture, breeding strategy and the number of initial parents involved in the breeding program. Generally, maximum accuracies were achieved under a mass selection strategy followed by pedigree and single seed descent methods. Model updating benefitted some breeding strategies more than others (e.g., single seed descent vs mass selection). For low heritability traits (i.e., yield), conventional methods provided comparable rates of genetic gain, but genetic gain under genomic selection reached a plateau in a lower number of cycles.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.006
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Simulation or modeling · Consensus signal: Simulation or modeling
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.029
Threshold uncertainty score0.057

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.006
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0010.001
Open science0.0010.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.068
GPT teacher head0.397
Teacher spread0.329 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designSimulation or modeling
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2022
Admission routes1
Has abstractyes

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