Bibliographic record
Abstract
Ischemic stroke constitutes a leading cause of death and disability of the adults.Interruption of the blood supply caused by a thrombus or emboli leads to ischemia followed by reperfusion, which jointly generate an infarct core surrounded by a salvageable penumbra. 1Non-vascular and vascular cells as well as extracellular matrix (ECM) proteins work in concert to generate critical neurovascular functions, such as regulation of blood brain barrier (BBB), cerebral blood flow (CBF), vascular stability, and inflammation. 2Currently, recanalization is achieved through thrombolysis using tissue plasminogen activator (tPA) or endovascular thrombectomy (EVT). 3Nonetheless, the restrictive eligibility criteria of these standard gold interventions limit their broad clinical use.Furthermore, despite successful recanalization, infarct could still progress due to neurovascular deregulation associated with reperfusion-mediated injury.Evidence is suggesting that the crosstalk between thromboembolism and inflammation represents a major culprit in stroke progression. 4Elucidating the mechanisms underlying this pathological crosstalk would allow achieving breakthroughs in stroke therapies through new interventions that aim at attenuating neurovascular deregulation.Upon endothelial injury, thromboembolism is initiated following exposure of ECM proteins, such as fibronectin and collagen, allowing the activation, adhesion, and aggregation of platelets.Platelet receptor glycoprotein (GP)Ib interaction with von Willebrand factor (vWF) reduces platelet velocity at the injured microvasculature and promotes their interaction with collagen via immunoglobulin superfamily receptor GPVI. 4 The release of agonists further enhances the activation and recruitment of additional platelets.The subsequent increased expression of integrin adhesion receptors stabilizes platelet adhesion and facilitates their aggregation by binding www.thelancet.com
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.002 |
| Insufficient payload (model declined to judge) | 0.008 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".