← Back to cohort
Discontinuation versus continuation of hypertonic saline or dornase alfa in modulator treated people with cystic fibrosis (SIMPLIFY): results from two parallel, multicentre, open-label, randomised, controlled, non-inferiority trials
Nicole Mayer-Hamblett, Félix Ratjen, Renee Russell, Scott H. Donaldson, Kristin A. Riekert, Gregory S. Sawicki, Katherine Odem‐Davis, J. Young, Daniel Rosenbluth, Jennifer L. Taylor‐Cousar, Christopher H. Goss, George Retsch‐Bogart, John Clancy, Alan Genatossio, Brian O’Sullivan, Ariel Berlinski, Susan L. Millard, Gregory J. Omlor, Colby A Wyatt, Kathryn Moffett, David P. Nichols, Alex H. Gifford, Margaret Kloster, Katie Weaver, Claire Chapdu, Jing Xie, M. Skalland, Melita Romasco, Sonya L. Heltshe, Noah Simon, Jill M. VanDalfsen, Anna Mead, Rachael Buckingham, Kathy Seidel, Nikita Midamba, Laurel Couture, Brooke Zappone Case, Wendy Au, Elsie Rockers, Diane Cooke, Amber Olander, Irene Bondick, Miya Johnson, Lisya VanHousen, Boris Nicholson, Michelle Parrish, Dion Roberts, Jillian Head, Jessica Carey, Lindsay J. Caverly, Joy Dangerfield, Rachel W. Linnemann, Jason Fullmer, Chelsea Roman, Peter J. Mogayzel, Deanne Reyes, Amy Harmala, Jerimiah Lysinger, Jonathan Bergeron, Isabel Virella‐Lowell, Perry Brown, Lejla Godusevic, Alicia Casey, Lauren Paquette, Thomas Lahiri, Julie Sweet, Joshua D. Harris, Shelia Parnell, Sylvia Szentpetery, Deborah Froh, Erica Tharrington, Manu Jain, Rachel Nelson, Sharon Kadon, Gary L. McPhail, Kimberly McBennett, Tia Rone, Elliott C. Dasenbrook, D. J. Weaver, Terri Johnson, Karen McCoy, Raksha Jain, Maria Mcleod, Mary Klosterman, Preeti Sharma, Amy Jones, Gary A. Mueller, Rachel Janney, Mary Cross, Jordana E. Hoppe, James F. Cahill, Zubin Mukadam, Jill Finto, Karen D. Schultz, Silvia Delgado Villalta, Alexa Smith, Gavin R. Graff, Diane Kitch, Don B. Sanders, Misty Thompson, Tahuanty Peña, M. Teresi, Jennifer Gafford, David J. Schaeffer, Joel Mermis, Lawrence T. Scott, Hugo Murua Escobar, Kristen M. Williams, Dana B. Dorman, Ryan Bethay, Zoran Danov, Kat Turbeville, Jimmy Johannes, Angelica Rodriguez, Bridget Marra, Robert Zanni, Ronald Morton, Terri Simeon, Andrew T. Braun, Nicole Dondlinger, Julie Biller, Erin Hubertz, Nicholas Antos, Laura Roth, Joanne Billings, Catherine Larson, Priya Balaji, John McNamara, Tammy J. Clark, Rebecca Griffith, Nancy E. Martinez, Sabiha Hussain, Halina Malveaux, Marie E. Egan, Catalina Guzman, J. DeCelie-Germana, Susan Galvin, Adrienne P. Savant, Nicole Falgout, Patricia Walker, Teresa DeMarco, Emily DiMango, Maria Ycaza, Julie Ballo, Pornchai Tirakitsoontorn, Daniel Layish, Desiree Serr, F. R. Livingston, Sherry Wooldridge, Carlos Milla, Jacquelyn Spano, Rebecca L. Davis, Okan Elidemir, Subramanyam Chittivelu, Ashley Scott, Sarah Alam, Daniel Dorgan, Matt Butoryak, Daniel J. Weiner, Harmony Renna, Brendan Klein, Anne J. Stone, Meg Lessard, Michael S. Schechter, Barbara Johnson, Steven R. Scofield, Theodore G. Liou, Jane B. Vroom, Kathryn Akong, Marissa Gil, Legna Betancourt, Jonathan P. Singer, Ngoc P. Ly, Courtney C. Moreno, Moira L. Aitken, Teresa E Gambol, Ronald L. Gibson, Allison Lambert, Joan Milton, Sarah Smith, Deanna Green, Diana Hodge, Christopher N. Fortner, Mary Forell, Rachel Karlnoski, K. Patel, Cori Daines, Elizabeth P. Ryan, Rodolfo Amaro-Galvez, Elizabeth Dohanich, Alison Lennox, Zachary Messer, Holly Hanes, Kay Powell, Deepika Polineni
Bibliographic record
VenueThe Lancet Respiratory Medicine · 2022
Typearticle
Languageen
FieldMedicine
TopicCystic Fibrosis Research Advances
Canadian institutionsHospital for Sick Children
FundersNational Center for Advancing Translational SciencesNational Institute of Diabetes and Digestive and Kidney DiseasesChiesi USANational Institutes of HealthNabriva TherapeuticsVertex PharmaceuticalsInsmedGilead SciencesCystic Fibrosis FoundationGenentechAstraZenecaGlaxoSmithKlineNational Heart, Lung, and Blood InstituteAmerican Thoracic Society
KeywordsMedicineHypertonic salineCystic fibrosisDiscontinuationRandomized controlled trialIvacaftorClinical trialInternal medicinePhysical therapyCystic fibrosis transmembrane conductance regulator
Abstract
No abstract in any covered source. Its absence is recorded, not treated as a negative.
No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
metaresearch head score (Codex)0.009
metaresearch head score (Gemma)0.029
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch, Meta-epidemiology (narrow), Insufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.040
Threshold uncertainty score1.000
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.009 | 0.029 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.004 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.110
GPT teacher head0.396
Teacher spread0.286 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
Study designRandomized trial
Domainnot available
GenreEmpirical
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
Quick stats
Citations126
Published2022
Admission routes1
Has abstractno