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Publisher Correction: Stroke genetics informs drug discovery and risk prediction across ancestries
Aniket Mishra, Rainer Malik, Tsuyoshi Hachiya, Tuuli Jürgenson, Shinichi Namba, Daniel Posner, Frederick Kamanu, Masaru Koido, Quentin Le Grand, Mingyang Shi, Yunye He, Marios K. Georgakis, Ilana Caro, Kristi Krebs, Yi‐Ching Liaw, Felix Vaura, Kuang Lin, Bendik S. Winsvold, Vinodh Srinivasasainagendra, Livia Parodi, Hee‐Joon Bae, Ganesh Chauhan, Michael Chong, Liisa Tomppo, Rufus Akinyemi, Gennady V. Roshchupkin, Naomi Habib, Yon Ho Jee, Jesper Qvist Thomassen, Vida Abedi, Jara Cárcel‐Márquez, Marianne Nygaard, Hampton L. Leonard, Chaojie Yang, Ekaterina Yonova-Doing, Maria J. Knol, Adam Lewis, Renae Judy, Tetsuro Ago, Philippe Amouyel, Nicole D. Armstrong, Mark K. Bakker, Traci M. Bartz, David A. Bennett, Joshua C. Bis, Constance Bordes, Sigrid Børte, Anael Cain, Paul M. Ridker, Kelly Cho, Zhengming Chen, Carlos Cruchaga, John W. Cole, Phil L. De Jager, Matthias Endres, Leslie Ecker Ferreira, Mirjam I. Geerlings, Natalie C. Gasca, Vilmundur Guðnason, Jun Hata, Jing He, Alicia K. Heath, Yuk‐Lam Ho, Aki S. Havulinna, Jemma C. Hopewell, Hyacinth I. Hyacinth, Michael Inouye, Mina A. Jacob, Christina Jeon, Christina Jern, Masahiro Kamouchi, Keith L. Keene, Takanari Kitazono, Steven J. Kittner, Takahiro Konuma, Amit Kumar, Paul Lacaze, Lenore J. Launer, Keon‐Joo Lee, Kaido Lepik, Jiang Li, Liming Li, Ani Manichaikul, Hugh S. Markus, Nicholas Marston, Thomas Meitinger, Braxton D. Mitchell, Felipe A. Montellano, Takayuki Morisaki, Thomas H. Mosley, Mike A. Nalls, Børge G. Nordestgaard, Martin O’Donnell, Yukinori Okada, N. Charlotte Onland‐Moret, Bruce Ovbiagele, Annette Peters, Bruce M. Psaty, Stephen S. Rich, Jonathan Rosand, Marc S. Sabatine, Ralph L. Sacco, Danish Saleheen, Else Charlotte Sandset, Veikko Salomaa, Muralidharan Sargurupremraj, Makoto Sasaki, Claudia L. Satizábal, Carsten Oliver Schmidt, Atsushi Shimizu, Nicholas L. Smith, Kelly L. Sloane, Yoichi Sutoh, Yan V. Sun, Kozo Tanno, Steffen Tiedt, Turgut Tatlisumak, Nuria P. Torres‐Aguila, Hemant K. Tiwari, David‐Alexandre Trégouët, Stella Trompet, Anil M Tuladhar, Anne Tybjærg‐Hansen, Marion van Vugt, Riina Vibo, Shefali S. Verma, Kerri L. Wiggins, Patrik Wennberg, Daniel Woo, Peter W.F. Wilson, Huichun Xu, Qiong Yang, Kyungheon Yoon, Jin‐Moo Lee, Yu-Ching Cheng, James F. Meschia, Wei Min Chen, Michèle M. Sale, Alan B. Zonderman, Michele K. Evans, James G. Wilson, Adolfo Correa, Matthew Traylor, Cathryn M. Lewis, Cara L. Carty, Alexander Reiner, Jeffrey Haessler, Carl D. Langefeld, Rebecca F. Gottesman, Kristine Yaffe, Yong Mei Liu, Leslie A. Lange, Karen L. Furie, Donna K. Arnett, Oscar Benavente, Raji P. Grewal, Leema Reddy Peddareddygari, Kristian Hveem, Sara Lindström, Lu Wang, Erin N. Smith, William Gordon, Astrid van Hylckama Vlieg, Mariza de Andrade, Jennifer A. Brody, Jack Pattee, Ben Brumpton, Pierre Suchon, Ming‐Huei Chen, Kelly A. Frazer, Constance Turman, Marine Germain, James MacDonald, Sigrid K. Brækkan, Sebastian M. Armasu, Nathan Pankratz, Rebecca D. 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Butterworth, Laura Heitsch, Giorgio B. Boncoraglio, Michiaki Kubo, Alessandro Pezzini, Arndt Rolfs, Anne‐Katrin Giese, David R. Weir, Owen A. Ross, Robin Lemmons, Martin Söderholm, Mary Cushman, Katarina Jood, Caitrin W. McDonough, Steven Bell, Birgit Linkohr, Tsong-Hai Lee, Jukka Putaala, Christopher D. Anderson, Oscar L. López, Xueqiu Jian, Ulf Schminke, Natàlia Cullell, Pilar Delgado, Laura Ibáñez, Jerzy Krupiński, Vasileios Lioutas, Koichi Matsuda, Joan Montaner, Elena Muiño, Jaume Roquer, Chloé Sarnowski, Naveed Sattar, Gerli Sibolt, Alexander Teumer, Loes C.A. Rutten‐Jacobs, Masahiro Kanai, Sólveig Grétarsdóttir, Natalia S. Rost, Salim Yusuf, Peter Almgren, Hakan Ay, Steve Bevan, Robert D. Brown, Caty Carrera, Julie E. Buring, Wei‐Min Chen, Ioana Cotlarciuc, Paul I. W. de Bakker, Anita L. DeStefano, Marcel den Hoed, Qing Duan, Stefan T. Engelter, Guido J. Falcone, Stefan Gustafsson, Ahamad Hassan, George Howard, Fang‐Chi Hsu, Erik Ingelsson, Tamara B. Harris, Brett Kissela, Dawn Kleindorfer, Claudia Langenberg, Robin Lemmens, Didier Leys, Wei‐Yu Lin, Erik Lorentzen, Patrik K. E. Magnusson, Patrick F. McArdle, Sara L. Pulit, Kenneth Rice, Saori Sakaue, Bishwa R. Sapkota, Christian Tanislav, Guðmar Þorleifsson, Unnur Þorsteinsdóttir, Christophe Tzourio, Cornelia M. van Duijn, Matthew Walters, Nicholas J. Wareham, Najaf Amin, Hugo J. Aparicio, John Attia, Claudine Berr, Mariana Bustamante, Valeria Caso, Seung Hoan Choi, Ayesha Chowhan, Jean‐François Dartigues, Hossein Delavaran, Marcus Dörr, Ian Ford, Wander S. Gurpreet, Anders Hamsten, Atsushi Hozawa, Martin Ingelsson, Motoki Iwasaki, Sara Kaffashian, Lalit Kalra, Ólafur Kjartansson, Manja Kloß, Daniel Labovitz, Cathy C. Laurie, Linxin Li, Lars Lind, Cecilia M. Lindgren, Makoto Hirata, Naoko Minegishi, Andrew P. Morris, Martina Müller‐Nurasyid, Bo Norrving, Soichi Ogishima, Eugenio Parati, Nancy L. Pedersen, Markus Perola, Silvana Pileggi, Raquel Rabionet, Iolanda Riba‐Llena, Marta Ribasés, José R. Romero, Anthony Rudd, Antti‐Pekka Sarin, Sarju Ralhan, Mamoru Satoh, Norie Sawada, Ásgeir Sigurðsson, Albert V. Smith, O. Colin Stine, David J. Stott, Konstantin Strauch, Takako Takai, Hideo Tanaka, Emmanuel Touzé, Shoichiro Tsugane, André G. Uitterlinden, Einar Már Valdimarsson, Sven J. van der Lee, Kenji Wakai, Stephen R. Williams, Charles Wolfe, Quenna Wong, Taiki Yamaji, Dharambir K. Sanghera, Kāri Stefánsson, Nicolas Martinez‐Majander, Kenji Sobue, Carolina Soriano‐Tárraga, Henry Völzke, Onoja Akpa, Fred Stephen Sarfo, Albert Akpalu, Reginald Obiako, Kolawole Wahab, Godwin Osaigbovo, Lukman Owolabi, Morenikeji Komolafe, Carolyn Jenkins, Oyedunni Arulogun, Godwin Ogbole, Abiodun M. Adeoye, Joshua Akinyemi, Atinuke Agunloye, Adekunle Fakunle, Ezinne Uvere, Abimbola Olalere, Olayinka Adebajo, Junshi Chen, Robert Clarke, Rory Collins, Yu Guo, Chen Wang, Jun Lv, Richard Peto, Yiping Chen, Zammy Fairhurst-Hunter, Michael A. Hill, Alfred Pozarickij, Dan Schmidt, Becky Stevens, Iain Turnbull, Canqing Yu, Akiko Nagai, Yoishinori Murakami, Eric J. Shiroma, Sigurður Sigurðsson, Mohsen Ghanbari, Eric Boerwinkle, Bernard Fongang, Ruiqi Wang, M. Kamran Ikram, Uwe Völker, Karlijn F. de Laat, Anouk G.W. van Norden, Paul L.M. de Kort, Sarah E. Vermeer, Paul J.A.M. Brouwers, Rob A.R. Gons, Tom den Heijer, Gert W. van Dijk, Frank G. W. van Rooij, Anne Hege Aamodt, Anne Heidi Skogholt, Cristen J. Willer, Ingrid Heuch, Knut Hagen, Lars G. Fritsche, Linda M. Pedersen, Hanne Ellekjær, Wei Zhou, Amy E. Martinsen, Espen Saxhaug Kristoffersen, Laurent F. 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Bibliographic record
VenueNature · 2022
Typeerratum
Languageen
FieldMedicine
TopicCerebrovascular and genetic disorders
Canadian institutionsMcGill Genome CentrePopulation Health Research InstituteMcMaster UniversityImpactMcGill UniversityUniversity of British ColumbiaThrombosis and Atherosclerosis Research Institute
FundersNational Human Genome Research InstituteMedical Research CouncilAgence Nationale de la RechercheLundbeckfondenBritish Heart FoundationWellcome Trust
KeywordsDrug discoveryComputational biologyDrugGeneticsBiologyMedicineBioinformaticsPharmacology
Abstract
In the version of this article initially published, the name of the PRECISE4Q Consortium was misspelled as “PRECISEQ” and has now been amended in the HTML and PDF versions of the article. Further, data in the first column of Supplementary Table 55 were mistakenly shifted and have been corrected in the file accompanying the HTML version of the article.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow), Research integrity
Consensus categoriesResearch integrity
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Other · Consensus signal: none
Teacher disagreement score0.771
Threshold uncertainty score1.000
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.002 | 0.009 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.004
GPT teacher head0.244
Teacher spread0.240 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
Study designNot applicable
Domainnot available
GenreOther
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
Quick stats
Citations12
Published2022
Admission routes1
Has abstractyes