Inventing and Building HTE Technology for End-Users: The Merck/Analytical Sales and Services Collaboration — An Interview
Bibliographic record
Abstract
This chapter showcases the many examples in which collaborations between scientists in small molecule process and medicinal chemistry, technology inventors at Merck & Co. (known as MSD outside of the U.S. and Canada) and engineers at Analytical Sales and Services have provided technological solutions for the high throughput experimentation (HTE) field. Illustrated by figures of the devices and solutions that were developed over many years under the framework of this collaboration, this chapter is a transcript of a recorded virtual interview that took place on November 30, 2021. Most of the devices discussed are now commercially available and benefit HTE users worldwide. The conversation explores the technical, scientific, business, and human aspects of collaboration, aiming to provide intimate insight into the reasons for the success of the ongoing partnership.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.007 | 0.006 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.015 | 0.009 |
| Scholarly communication | 0.009 | 0.010 |
| Open science | 0.002 | 0.007 |
| Research integrity | 0.005 | 0.009 |
| Insufficient payload (model declined to judge) | 0.008 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".