[Retracted] Correlation Analysis of Inflammatory Markers CRP and IL‐6 and Postoperative Delirium (POD) in Elderly Patients: A Meta‐Analysis of Observational Studies
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A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
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Post-publication record
- Nature
- Retraction
- Reason
- Concerns/Issues about Data;Concerns/Issues about Results and/or Conclusions;Concerns/Issues about Referencing/Attributions;Concerns/Issues about Peer Review;Investigation by Journal/Publisher;Investigation by Third Party;Computer-Aided Content or Computer-Generated Content;Unreliable Results and/or Conclusions;
- Date
- 7/12/2023 0:00
- Flagged by OpenAlex?
- Yes
Source: Retraction Watch, joined by DOI. OpenAlex records retraction as is_retracted, a boolean over a state space with at least four values, so it cannot express an expression of concern, a correction or a reinstatement — it reports them as false, which reads as “fine”.
Abstract
Background . Postoperative delirium (POD) is very common in the elderly surgical population, and its occurrence is associated with multiple factors such as preoperative, intraoperative, and postoperative factors, and the increase of serum inflammatory markers such as C‐reactive protein (CRP) and interleukin‐6 (IL‐6) is considered to be associated with the occurrence of POD, but the results of multiple studies are inconsistent. In this study, we investigated the correlation between inflammatory markers CRP and IL‐6 and POD in elderly patients by literature search and meta‐analysis. Methods . We searched PubMed, Web of Science, the Cochrane library, Embase, Ovid, and Springer Link for cohort studies or case‐control studies that investigated the factors involved in the occurrence of POD, used the Newcastle‐Ottawa Scale (NOS) to assess the quality of the selected literature, and combined the differences in serum CRP and IL‐6 levels between POD and non‐POD patients after surgery to evaluate the predictive value of CRP and IL‐6 for the occurrence of POD. Results . This research comprised 16 papers for quantitative analysis, with a total of 2967 patients, 758 with POD and 2209 with non‐POD. There were 16 cohort studies (100%) and 0 case‐control studies (0%) across all the collected literatures; there were 15 prospective cohort studies and 1 retrospective cohort research. A meta‐analysis revealed a statistically significant difference in serum IL‐6 levels between POD patients after surgery and non‐POD patients [MD = 115.68, 95% CI (25.70, 206.66), Z = 2.52, P = 0.012], as well as a statistically significant difference in serum CRP levels [MD = 27.67, 95% CI (12.77, 42.58), Z = 3.64, P = 0.0003]. Discussion . Early after surgery, serum IL‐6 and CRP levels were considerably higher in POD patients than in non‐POD patients, indicating that early serum inflammatory variables are likely to be predictors of POD. After surgery, the levels of the aforementioned inflammatory factors should be actively monitored to forecast the emergence of delirium, and active treatment should be used to limit the creation and release of the aforementioned inflammatory factors.
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The record
- Venue
- Journal of Environmental and Public Health
- Topic
- Intensive Care Unit Cognitive Disorders
- Field
- Medicine
- Canadian institutions
- —
- Funders
- —
- Keywords
- MedicinePoint of deliveryMeta-analysisInternal medicineCochrane LibraryCohort studyProspective cohort studyDeliriumPopulationGastroenterologyIntensive care medicineBiologyEnvironmental health
- Has abstract in OpenAlex
- yes