The Subline of Metastatic Prostate Cancer Cell line, DU145 expresses Tks4 and reveals distinctive Phenotype
Bibliographic record
Abstract
Cancer metastasis is the process of dissemination of cancer cells from their original site and localization in distant sites. During this journey, metastatic cancer cells have to undergo several phenotypical/ genotypical changes for acquiring cell migration, invasion, attachment properties etc. These steps can be partially/fully mimicked under in vivo and in vitro conditions. Here, we injected metastatic prostate cancer cell line, DU145, into the chorioallantoic membrane )CAM( of the chicken embryo to generate sublines which were isolated 7-days post-injection, and subcultured under in vitro conditions. Our results showed that one of these sublines, DC-1-, exhibited a distinctive phenotype compared with the parental cell line when grown in 3D culture model. Further, the expression of Tks4 at the mRNA and protein level in DC-1- cells was observed to be higher than the regular DU145 cells. Keywords: Prostate cancer, DU145, DC-1-, Metastasis, Round, Stellate, Colony, Tks4
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".