Bibliographic record
Abstract
Host-parasite-vector interactions: Invasion and persistenceThis Research Topic, Frontiers in Host-Parasite-Vector Interactions: Invasion and Persistence, received six articles, including four original research studies and two reviews.All four original articles and one review paper relate to the intracellular protozoan parasite Leishmania, its interaction with the host, and resulting pathogenesis.The other review article updates our understanding of the biochemical and physiological mechanism of gametogenesis in Plasmodium, which could be targeted to control parasite and malaria transmission, and highlights gaps that still exist within our understanding of the process of gametogenesis.Together, these articles are related to protozoan parasites causing human diseases.This is not surprising as parasitic infections are responsible for severe mortality and morbidity worldwide, particularly in developing countries.In fact, millions of lives are lost due to parasitic infections each year, and most mortality and morbidity are due to protozoan infections.Most protozoan infections are caused by Leishmania spp., Plasmodium spp., and Trypanosoma spp.These pathogens can establish persistent and sometimes long-term infections.Several of these intracellular pathogens have developed diverse immune escape strategies and can overcome immune responses by residing and replicating inside host immune cells, primarily mononuclear phagocytic macrophages.Although macrophages are armed with potent anti-infection properties, there are certain microbial pathogens, including several parasites like Leishmania spp.and Trypanosoma spp., that are capable of actively infecting these hostile cells.To establish infection, these intracellular parasites must first find ways to enter their host cells.For example, some pathogens (Leishmania, Trypanosoma) exploit phagocytic pathways by engaging specific phagocytic receptors.Once inside, these pathogens must employ clever strategies to survive, grow, and replicate in a hostile intracellular environment.Such strategies include deactivating the host cells by modulating host response by subverting intracellular signal transduction pathways of activation.A deeper understanding of the immune evasion mechanisms used by these devastating protozoan parasites can pave the Frontiers in Cellular and Infection Microbiology frontiersin.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.004 | 0.011 |
| Meta-epidemiology (narrow) | 0.005 | 0.001 |
| Meta-epidemiology (broad) | 0.003 | 0.002 |
| Bibliometrics | 0.003 | 0.001 |
| Science and technology studies | 0.002 | 0.002 |
| Scholarly communication | 0.005 | 0.004 |
| Open science | 0.003 | 0.001 |
| Research integrity | 0.008 | 0.011 |
| Insufficient payload (model declined to judge) | 0.015 | 0.012 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".