Record W4310063611 · doi:10.1016/j.thromres.2022.11.016

36-month clinical outcomes of patients with venous thromboembolism: GARFIELD-VTE

2022· article· en· W4310063611 on OpenAlexafffund

Alexander G.G. Turpie, Alfredo E. Farjat, Sylvia Haas, Walter Ageno, Jeffrey I. Weitz, Samuel Z. Goldhaber, Shinya Goto, Pantep Angchaisuksiri, Gloria Kayani, Renato D. Lópes, Chern‐En Chiang, Harry Gibbs, Eric Tse, Peter Verhamme, Hugo Ten Cate, Juan Muntaner, Sebastian Schellong, Henri Bounameaux, Paolo Prandoni, Uma Maheshwari, Ajay K. Kakkar, A. Loualidi, Abdürrahim Çolak, Abraham F. Bezuidenhout, A.T.O. Abdool-Carrim, Addala Azeddine, Adriaan Beyers, A Dees, Ahmed Mohamed, Ahmet Aksoy, Akihiko Abiko, Akinori Watanabe, Alan Krichell, Alberto Alfredo Fernandez, Alberto Tosetto, Alexey Khotuntsov, Alisha Oropallo, Alison Slocombe, Allan Kelly, Amanda Clark, Amr Gad, Amy Arouni, Andor Schmidt, Andrea Berni, Andres Javier Kleiban, A Machowski, Andrey Kazakov, Ángel Gálvez, Ann Lockman, Anna Falanga, Anoop Chauhan, Antoni Riera‐Mestre, Antonino Mazzone, Armando D’Angelo, Artur Haddad Herdy, Atsushi Kato, Ayman Abd Elhamid Ebrahim Mahmoud Salem, Azlan Husin, Barbara Erdelyi, Barry Jacobson, Beatrice Amann‐Vesti, Bektaş Battaloǧlu, Benedicte Wilson, Benilde Cosmi, Bergmann Jean Francois, Berremeli Toufek, Beverley Hunt, Bhavesh Natha, Bisher Mustafa, Bonnie Chi Shan Kho, Boulon Carine, Brian Zidel, Brisot Dominique, Brousse Christophe, Bruno Trimarco, Canhua Luo, Carlos Alberto Cuneo, Carsten Schwencke, Cas Cader, Celal Yavuz, Cesar Javier Zaidman, Charles A. Lunn, Chau‐Chung Wu, Cheng Hock Toh, Chevrier Elisa, Chien‐Hsun Hsia, Chien-Lung Huang, Chi‐Hang Kevin Kwok, Chih-Cheng Wu, Chi‐Hung Huang, Chris Ward, Christian Opitz, Christina Jeanneret‐Gris, Chung Yin Ha, Chun‐Yao Huang, Claude Luyeye Bidi, Clifford Smith, Cornelia Brauer, Corrado Lodigiani, Françis Couturaud, Cynthia Wu, Daniel Staub, Daniel Theodoro, Daniela Poli, David Acevedo, David Adler, David Jiménez, David Keeling, David Scott, Davide Imberti, Desmond Creagh, Desmurs‐Clavel Helene, Dirk Hagemann, Dirk Le Roux, Dirk Skowasch, Dmitry Belenky, Dmitry Dorokhov, Dmitry Petrov, D. A. Zateyshchikov, Domenico Prisco, Dorthe Svenstrup Møller, Dusan Kucera, Ehab M. Esheiba, Е. П. Панченко, Elkouri Dominique, Emre Doğan, Emre Kubat, Enrique Diaz Diaz, Eric Wai Choi Tse, Erik Yeo, Erman Hashas, Ernst Gröchenig, Eros Tiraferri, Erwin Blessing, E Michele, Esther Usandizaga, Ettore Porreca, Fabián Ferroni, Falvo Nicolas, Félix Ayala-Paredes, Firas Koura, Fitjerald Henry, Franco Cosmi, Frans Erdkamp, Gadel Kamalov, Garcia‐Bragado Dalmau, Garrigues Damien, Garry Klein, Gaurand Shah, Geert Hollanders, Geno J. Merli, Georg Plassmann, George Platt, Germain Poirier, German Sokurenko, Ghassan Haddad, Gholam Ali, Giancarlo Agnelli, Gin Gin Gan, Grace Kaye‐Eddie, Grégoire Le Gal, Gregory Allen, Guillermo Antonio Llamas Esperón, Guillot Jean‐Paul, Hagen Gerofke, Hallah Elali, Hana Burianová, Hans‐Juergen Ohler, Haofu Wang, Harald Darius, Harinder Gogia, Harry Striekwold, Hatice Canan Hasanoğlu, Hatice Türker, Hendrik Franow, Herbert De Raedt, Herman Schroë, Hesham Salah ElDin, Hesham Zidan, Hiroaki Nakamura, Ho Young Kim, Holger Lawall, Hong Zhu, Hongyan Tian, Ho‐Young Yhim, Hun-Gyu Hwang, Hyeok Shim, Igor Kim, И. А. Либов, Igor Sonkin, I.А. Suchkov, Ik‐Chan Song, İlker Kiriş, И Н Староверов, Irene Looi, Isabel M. De La Azuela Tenorio, İsmail Savaş, И. Г. Гордеев, Ivo Podpera, Jae Hoon Lee, Jameela Sathar, James Welker, Jan Beyer‐Westendorf, J Kvasnička, Jan Vanwelden, J.I. Kim, Jaromira Svobodova, Jaspal Gujral, Javier Marino, Javier Tristan Galvar, Jeannine Kassis, Jen‐Yuan Kuo, Jhih-Yuan Shih, Jihyun Kwon, Jin Hyun Joh, Jin Hyun Park, Jin Seok Kim, Jinghua Yang, J Krupicka, Jiří Laštůvka, Jiri Pumprla, Jiří Veselý, João Antônio Corrêa, Johan Duchateau, John Perry Fletcher, J. del Toro, Jorge Guillermo Chavez Paez, Jørn Dalsgaard Nielsen, Jose Dalmo Araujo Filho, José Francisco Kerr Saraiva, José Antonio Díaz Peromingo, Jose Lara, José Luis Fedele, José María Suriñach, Joseph Chacko, Juan Carlos Álvarez Benitez, Juan Moreno Hoyos Abril, Julian Humphrey, Julio Bono, Junji Kanda, Juree Boondumrongsagoon, Kai Hang Yiu, Kanchana Chansung, Karin A. Boomars, Kate Burbury, Katsuhiro Kondo, Kemal Karaarslan, Kensuke Takeuchi, Knut Kroeger, Konstantin Zrazhevskiy, Koscál Svatopluk, Kou‐Gi Shyu, Kristel Vandenbosch, Kuan‐Cheng Chang, Kuan‐Ming Chiu, Kubina Jean‐Manuel, Kwo‐Chang Ueng, Lalita Norasetthada, L Binet, Lee Ping Chew, Lei Zhang, Leone Maria Cristina, Lidwine W. Tick, Lilia Beatriz Schiavi, Lily Lee Lee Wong, Lohana Borges, Louis Botha, Luc Capiau, Luc Timmermans, Luciano Eduardo López, Luigi Ria, Luis Blasco, Luis Alberto Guzman, Luis Flota Cervera, Mahe Isabelle, Manuel Monreal Bosch, Manuel de los Rios Ibarra, Manuel Núñez Fernandez, Marc Carrier, Marcelo Barrionuevo, Marco Antonio Alcocer Gamba, Marco Cattaneo, Marco Moia, Margaret Bowers, Mariam Chetanachan, Mario Alberto Berli, Mark Fixley, Markus Faghih, Markus Stüecker, Marlin Schul, Martin Banyai, Martín Koretzky, Martin Myriam, Mary Elizabeth Gaffney, Masao Hirano, Masashi Kanemoto, Mashio Nakamura, Messas Emmanuel, Michael J. Kovacs, Michael F. Leahy, Michael L. Levy, Michael Munch, Michael Hecht Olsen, Michel De Pauw, Michel Gustin, Michiel Van Betsbrugge, Mikhail Boyarkin, Miroslav Homza, Modise Zacharia Koto, Mohamed Abdool‐Gaffar, Mohamed Nagib, M. Eldessoki, Mohamed Khan, Monniaty Mohamed, Moo Hyun Kim, Moon‐Hee Lee, Mosaad Soliman, Mostafa Shawky Ahmed, M. Bary, Moustafa A. Moustafa, Muhammad Hameed, Muhip Kanko, Mujibur Majumder, Nadezhda Zubareva, Nicola Mumoli, Nik Azim Nik Abdullah, Nisa Makruasi, Nishen Paruk, Nonglak Kanitsap, Norberto Duda, Ole Nyvad, О. Л. Барбараш, Orçun Gürbüz, Oscar Gómez Vilamajó, Oscar Nandayapa Flores, Özcan Gür, Öztekin Oto, Pablo Javier Marchena, Patrick Carroll, Pavel Lang, Peter MacCallum, Peter Baron von Bilderling, Peter Blombery, Petr Janský, Peuch Bernadette, Philippe De Vleeschauwer, Piera Maria Ferrini, Piriyaporn Iamsai, Ponchaux Christian, Pongtep Viboonjuntra, Ponlapat Rojnuckarin, Prahlad Ho, Pramook Mutirangura, Rachel Wells, Rafael Martínez, Raimundo Tirado Miranda, Ralf Kroening, Rapule Ratsela, Raquel López Reyes, Raúl León, Raymond Wong, Raz Alikhan, Reinhold Jerwan‐Keim, Remedios Otero, Renate Murena‐Schmidt, Reto Canevascini, Richard Ferkl, Richard White, R. van Herreweghe, Rita Santoro, Robert Klamroth, Robert Mendes, Robert Prosecký, Roberto Cappelli, R Spacek, Rupesh Kumar Singh, Sam Griffin, Sang Hoon Na, Sanjeev Chunilal, Saskia Middeldorp, Satoshi Nakazawa, See Guan Toh, Seinturier Christophe, Selim İşbir, Selma Regina de Oliveira Raymundo, Seng Kiat Ting, Serge Motte, Serir Aktoğu, S. H. J. Donders, Seung Ick, Seung‐Hyun Nam, Sevestre‐Pietri Marie‐Antoinette, Shaun Maasdorp, Shenghua Sun, Shenming Wang, Sherif Mohamed Essameldin, Sherif Sholkamy, Shintaro Kuki, Shuichi Yoshida, Shunzo Matsuoka, Simon McRae, Simon Watt, Siriwimon Patanasing, Siwe‐Nana Jean‐Léopold, Somchai Wongkhantee, Soo‐Mee Bang, Sophie Testa, Stanislav Zemek, Steffen Behrens, Stephan Dominique, Stuart Mellor, Suaran Singh Gurcharan Singh, Sudip Kumar Datta, Sunee Chayangsu, Susan Solymoss, Tamara Everington, Tarek Ahmed Adel Abdel‐Azim, Tawatchai Suwanban, Taylan Adademir, Terence Hart, Terriat Béatrice, Thifhelimbilu Emmanuel Luvhengo, Thomas Horacek, Thomas Zeller, Tim Boussy, Tim Reynolds, Tina Biss, Ting‐Hsing Chao, Tomas Smith Casabella, Tomoya Onodera, Tontanai Numbenjapon, Victor E. A. Gerdes, Vladimir Cech, Vladimir Krasavin, Vladimir Tolstikhin, Willem A. Bax, Wagih Fawzy Abdel Malek, Wai Khoon Ho, Walter Pharr, Weihong Jiang, Wei‐Hsiang Lin, Weihua Zhang, Wei‐Kung Tseng, Wen‐Ter Lai, Wilfried De Backer, Wilhelm Haverkamp, Winston Bonetti Yoshida, Wolfgang Korte, Won‐Il Choi, Yang‐Ki Kim, Yasuhiro Tanabe, Yasushi Ohnuma, Yeung‐Chul Mun, Yohan Balthazar, Yong Park, Yoshisato Shibata, Yuriy Burov, Yuriy Subbotin, Zdeněk Coufal, Zhenwen Yang, Zhi‐Cheng Jing, Zhong-Qi Yang

Bibliographic record

VenueThrombosis Research · 2022

Typearticle

Languageen

FieldMedicine

TopicVenous Thromboembolism Diagnosis and Management

Canadian institutionsThrombosis and Atherosclerosis Research InstituteMcMaster University

FundersServierDaiichi-SankyoMedtronicAlnylam PharmaceuticalsNational Heart, Lung, and Blood InstitutePfizerHeart and Stroke Foundation of CanadaGlaxoSmithKlineAmgenPharmaceuticals BayerAstraZenecaBristol-Myers SquibbBayerBayer HealthCareSanofiCanadian Institutes of Health ResearchAmerican Heart Association

KeywordsVenous thromboembolismMedicineIntensive care medicineInternal medicineCardiologyThrombosis

DOI10.1016/j.thromres.2022.11.016

Abstract

fetched live from OpenAlex

BACKGROUND: Venous thromboembolism (VTE), encompassing both deep vein thrombosis (DVT) and pulmonary embolism (PE), is a leading cause of morbidity and mortality worldwide. METHODS: GARFIELD-VTE is a prospective, non-interventional observational study of real-world treatment practices. We aimed to capture the 36-month clinical outcomes of 10,679 patients with objectively confirmed VTE enrolled between May 2014 and January 2017 from 415 sites in 28 countries. FINDINGS: A total of 6582 (61.6 %) patients had DVT alone, 4097 (38.4 %) had PE ± DVT. At baseline, 98.1 % of patients received anticoagulation (AC) with or without other modalities of therapy. The proportion of patients on AC therapy decreased over time: 87.6 % at 3 months, 73.0 % at 6 months, 54.2 % at 12 months and 42.0 % at 36 months. At 12-months follow-up, the incidences (95 % confidence interval [CI]) of all-cause mortality, recurrent VTE and major bleeding were 6.5 (7.0-8.1), 5.4 (4.9-5.9) and 2.7 (2.4-3.0) per 100 person-years, respectively. At 36-months, these decreased to 4.4 (4.2-4.7), 3.5 (3.2-2.7) and 1.4 (1.3-1.6) per 100 person-years, respectively. Over 36-months, the rate of all-cause mortality and major bleeds were highest in patients treated with parenteral therapy (PAR) versus oral anti-coagulants (OAC) and no OAC, and the rate of recurrent VTE was highest in patients on no OAC versus those on PAR and OAC. The most frequent cause of death after 36-month follow-up was cancer (n = 565, 48.6 %), followed by cardiac (n = 94, 8.1 %), and VTE (n = 38, 3.2 %). Most recurrent VTE events were DVT alone (n = 564, 63.3 %), with the remainder PE, (n = 236, 27.3 %), or PE in combination with DVT (n = 63, 7.3 %). INTERPRETATION: GARFIELD-VTE provides a global perspective of anticoagulation patterns and highlights the accumulation of events within the first 12 months after diagnosis. These findings may help identify treatment gaps for subsequent interventions to improve patient outcomes in this patient population.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.003

metaresearch head score (Gemma)0.000

Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated

Candidate categoriesInsufficient payload (model declined to judge)

Consensus categoriesnone

DomainCandidate signal: none · Consensus signal: none

Study designCandidate signal: Observational · Consensus signal: Observational

GenreCandidate signal: Empirical · Consensus signal: Empirical

Teacher disagreement score0.045

Threshold uncertainty score0.997

Codex and Gemma teacher scores by category

Category	Codex	Gemma
Metaresearch	0.003	0.000
Meta-epidemiology (narrow)	0.000	0.000
Meta-epidemiology (broad)	0.002	0.000
Bibliometrics	0.000	0.001
Science and technology studies	0.001	0.000
Scholarly communication	0.000	0.000
Open science	0.001	0.001
Research integrity	0.000	0.001
Insufficient payload (model declined to judge)	0.003	0.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.098

GPT teacher head0.416

Teacher spread0.317 · how far apart the two teachers sit on this one work

Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Insufficient payload (model declined to judge)

Study designObservational

Domainnot available

GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations26

Published2022

Admission routes2

Has abstractyes

Download record (JSON)Report an issue with this record

Explore more

Same venueThrombosis Research→Same topicVenous Thromboembolism Diagnosis and Management→French-language works237,207→