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Record W4310700273 · doi:10.1038/s41598-022-24870-7

Modulation of EEG theta by naturalistic social content is not altered in infants with family history of autism

2022· article· en· W4310700273 on OpenAlexaff
Rianne Haartsen, Tony Charman, Greg Pasco, Mark H. Johnson, Emily J. H. Jones, Simon Baron‐Cohen, Rachael Bedford, Anna Blasi, Patrick Bolton, Susie Chandler, Celeste H. M. Cheung, Kim Davies, Mayada Elsabbagh, Janice Fernandes, Issy Gammer, Holly Garwood, Teadora Gliga, Jeanne Guiraud, Melanie Liew, Sarah Lloyd‐Fox, Helen Maris, Louise O’Hara, Andrew Pickles, Helen Cristiny Teodoro Couto Ribeiro, Erica Salomone, Leslie Tucker, Ágnes Volein

Bibliographic record

VenueScientific Reports · 2022
Typearticle
Languageen
FieldNeuroscience
TopicAutism Spectrum Disorder Research
Canadian institutionsMcGill University
FundersHorizon 2020 Framework ProgrammeInnovative Medicines InitiativeEuropean CommissionAutism SpeaksInternational Seafood Sustainability FoundationSimons Foundation Autism Research InitiativeMedical Research CouncilEuropean Federation of Pharmaceutical Industries and AssociationsWellcome Trust
KeywordsAutismElectroencephalographyContent (measure theory)Autism spectrum disorderPsychologyFamily historyNaturalismAudiologyDevelopmental psychologyNeuroscienceMedicineInternal medicine

Abstract

fetched live from OpenAlex

Theta oscillations (spectral power and connectivity) are sensitive to the social content of an experience in typically developing infants, providing a possible marker of early social brain development. Autism is a neurodevelopmental condition affecting early social behaviour, but links to underlying social brain function remain unclear. We explored whether modulations of theta spectral power and connectivity by naturalistic social content in infancy are related to family history for autism. Fourteen-month-old infants with (family history; FH; N = 75) and without (no family history; NFH; N = 26) a first-degree relative with autism watched social and non-social videos during EEG recording. We calculated theta (4-5 Hz) spectral power and connectivity modulations (social-non-social) and associated them with outcomes at 36 months. We replicated previous findings of increased theta power and connectivity during social compared to non-social videos. Theta modulations with social content were similar between groups, for both power and connectivity. Together, these findings suggest that neural responses to naturalistic social stimuli may not be strongly altered in 14-month-old infants with family history of autism.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.004

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.063
GPT teacher head0.285
Teacher spread0.222 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations17
Published2022
Admission routes1
Has abstractyes

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