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Record W4310843539 · doi:10.5281/zenodo.7383627

Single-cell spatial landscapes of the lung tumour immune microenvironment

2022· article· en· W4310843539 on OpenAlexaff
Mark Sorin, Morteza Rezanejad, Elham Karimi, Benoit Fiset, Lysanne Desharnais, Lucas J. M. Perus, Simon Milette, Miranda Yu, Sarah M. Maritan, Samuel Dore, Émilie Pichette, William Enlow, Andréanne Gagné, Yuhong Wei, Michèle Orain, Venkata Manem, Roni Rayes, Peter M. Siegel, Sophie Camilleri‐Broët, Pierre Fiset, Patrice Desmeules, Jonathan Spicer, Daniela F. Quail, Philippe Joubert, Logan A. Walsh

Bibliographic record

VenueRePEc: Research Papers in Economics · 2022
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicSingle-cell and spatial transcriptomics
Canadian institutionsUniversité LavalInstitut universitaire de cardiologie et de pneumologie de QuébecMcGill University Health CentreUniversité du Québec à Trois-RivièresUniversity of TorontoMcGill University
Fundersnot available
KeywordsImmune systemLungCellBiologyGeographyMedicineImmunologyInternal medicineGenetics

Abstract

fetched live from OpenAlex

We updated our data set, please use the new version (md5:e33079d5299cdc17f37b9f5e4c08be12). All data supporting the findings of the publication "Single-cell spatial landscapes of the lung tumour immune microenvironment", including masks of high-dimension tif images, single-cell segmentation, single-cell cell types, and patient data. The code used to produce the results of this study is available at https://github.com/walsh-quail-labs/IMC-Lung. Channel index names: Channel Name Channel Index CD117 1 CD11c 2 CD14 3 CD163 4 CD16 5 CD20 6 CD31 7 CD3 8 CD4 9 CD68 10 CD8a 11 CD94 12 DNA1 13 FoxP3 14 HLA-DR 15 Histone H3 16 MPO 17 Pancytokeratin 18 TTF1 19

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.003
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.026
Threshold uncertainty score0.086

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.003
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.002
Science and technology studies0.0010.000
Scholarly communication0.0010.001
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0260.014

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.011
GPT teacher head0.226
Teacher spread0.215 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations18
Published2022
Admission routes1
Has abstractyes

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