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Record W4310873706 · doi:10.21203/rs.3.rs-2313037/v1

Comparison of Age and Modified Frailty Index-5 as Predictors of In-Hospital Mortality in Complete Traumatic Cervical Spinal Cord Injury

2022· preprint· en· W4310873706 on OpenAlexaff
Husain Shakil, Blessing N. R. Jaja, Peng F. Zhang, Rachael H. Jaffe, Armaan K. Malhotra, Erin M. Harrington, Jefferson R. Wilson, Christopher D. Witiw

Bibliographic record

VenueResearch Square · 2022
Typepreprint
Languageen
FieldMedicine
TopicTrauma and Emergency Care Studies
Canadian institutionsUniversity of Toronto
FundersAOSpine
KeywordsMedicineReceiver operating characteristicLogistic regressionRetrospective cohort studySpinal cord injuryInternal medicineEmergency medicineSpinal cord

Abstract

fetched live from OpenAlex

Abstract Frailty, as measured by the modified frailty index-5 (mFI-5), and older age are associated with increased mortality in the setting of spinal cord injury (SCI). However, a comparison of the predictive power of each measure has not been completed. We conducted a retrospective cohort study to evaluate in-hospital mortality among adult complete cervical SCI patients at participating centers of the Trauma Quality Improvement Program from 2010 to 2018. Logistic regression was used to predict in-hospital mortality, and the area under the Receiver Operating Characteristic curve (AUROC) of regression models with age, mFI-5, or age with mFI-5 was used to compare predictive power. 4,733 patients were eligible. We found significant effect of age > 75 years (OR 9.77 95% CI [7.21 13.29]) and mFI-5 ≥ 2 (OR 3.09 95% CI [1.85 4.99]) on in-hospital mortality. The AUROC of a model including age and mFI-5 (0.81 95%CI [0.79 0.84] AUROC) was comparable to a model with age alone (0.81 95%CI [0.79 0.83] AUROC). Both models were superior to a model with mFI-5 alone (0.75 95% CI [0.72 0.77] AUROC)). Our findings suggest that age provides more predictive power than mFI-5 in the prediction of in-hospital mortality for complete cervical SCI.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.005
metaresearch head score (Gemma)0.012
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.005
Threshold uncertainty score0.025

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0050.012
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.002
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0010.001
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.211
GPT teacher head0.491
Teacher spread0.281 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2022
Admission routes1
Has abstractyes

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