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Record W4310962312 · doi:10.1038/s41416-022-02022-y

Efficacy and safety of rucaparib treatment in patients with BRCA-mutated, relapsed ovarian cancer: final results from Study 10

2022· article· en· W4310962312 on OpenAlexafffund
Rebecca Kristeleit, Yvette Drew, Amit M. Oza, Susan M. Domchek, Susana Banerjee, Rosalind Glasspool, Judith Balmañà, Lee-may Chen, Manish R. Patel, Howard A. Burris, Tamar Safra, Jennifer Borrow, Kevin Lin, Sandra Goble, Lara Maloney, Ronnie Shapira‐Frommer

Bibliographic record

VenueBritish Journal of Cancer · 2022
Typearticle
Languageen
FieldMedicine
TopicPARP inhibition in cancer therapy
Canadian institutionsPrincess Margaret Cancer CentreUniversity Health NetworkBC Cancer Agency
FundersEMD SeronoGenentechFoundation MedicineSierra OncologyPharmaMarNewcastle UniversityMacroGenicsRelay TherapeuticsNGM BiopharmaceuticalsLoxo OncologyRibon TherapeuticsMersana TherapeuticsEisaiAdaptive BiotechnologiesPharmacyclicsAgios PharmaceuticalsSyndax PharmaceuticalsBeiGeneMirati TherapeuticsClovis OncologyDaiichi Sankyo EuropeGilead SciencesCalithera BiosciencesTG TherapeuticsModernaNuCanaPfizerHCA HealthcareIncyteTaiho PharmaceuticalMerck KGaAArray BioPharmaRevolution MedicinesExelixisGlaxoSmithKlineVerastem OncologyJounce TherapeuticsCelgeneAstraZenecaIgnytaEli Lilly and CompanyBristol-Myers Squibb
KeywordsMedicineInternal medicineOvarian cancerBRCA mutationAdverse effectOncologyCancerProgressive diseaseDisease

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Non-randomized trial · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.009

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.002
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0020.002
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0010.001
Open science0.0010.000
Research integrity0.0010.002
Insufficient payload (model declined to judge)0.0020.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.019
GPT teacher head0.293
Teacher spread0.274 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNon-randomized trial
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations9
Published2022
Admission routes2
Has abstractno

Explore more

Same venueBritish Journal of CancerSame topicPARP inhibition in cancer therapyFrench-language works237,207