Adénocarcinome du col utérin au Gabon : caractéristiques clinico-pathologiques d’une série des cas
Bibliographic record
Abstract
Contexte et objectifs. L’adénocarcinome du col utérin a fait l’objet de peu de publications notamment en Afrique. L’objectif de la présente étude était de décrire les aspects cliniques, pathologiques et évolutifs de ce cancer au Gabon puis d’évaluer la reproductibilité du pattern d’invasion (PI) afin d’améliorer le choix thérapeutique. Méthodes. Il s’agissait d’une série des cas d’adénocarcinomes du col utérin confirmés histologiquement en 8 ans. Les données clinico-pathologiques et le suivi ont été enregistrés à partir des dossiers médicaux. 3 pathologistes ont évalué le PI de chaque cas puis, la reproductibilité a été réalisée. Résultats. Sur les 378 cas recensés, 16 ont été retenus. Leur âge moyen était de 57 ans. Les femmes étaient de grandes multipares (68,7 %) et ayant consulté pour des métrorragies (87,5 %). Elles étaient récués à un stade clinique avancé (62,5 %) et l’évolution était défavorable dans 81,25 % des cas. Le type endocervical et le grade intermédiaire étaient les plus fréquents. Le niveau de concordance du PI était faible (28,6 %). Conclusion. L’adénocarcinome du col utérin au Gabon survient chez la femme d’âge jeune, grande multipare, est de diagnostic tardif et d’évolution péjorative d’où l’intérêt d’assurer un dépistage précoce et une prévention. Par ailleurs, la reproductibilité du PI devrait être réévaluée par des études supplémentaires. English title: Adenocarcinoma of the uterine cervix in Gabon: clinico-pathological characteristics of serial cases Context and objective. Little has been published on cervical adenocarcinoma, especially in Africa. The objective of the present study was to describe the clinical, pathological and follow-up aspects of this cancer in Gabon, then to evaluate the reproducibility of the invasion pattern (IP) in order to improve the therapeutic choice. Methods. It was a series of histologically confirmed cases of cervical adenocarcinoma over 8 years. Clinicopathological data and follow-up information were collected from medical records. 3 pathologists evaluated the IP of each case and then the reproducibility was carried out. Results. Of the 378 cases identified, 16 were selected. The average age was 57 years. The women were large multiparous (68.7 %), consulted for metrorrhagia (87.5%), had an advanced clinical stage (62.5 %) and evolution was often unfavourable (81.25%). Endocervical type and intermediate grade were the most frequent. The level of concordance of the IP was low (28.6 %). Conclusion. Adenocarcinoma of the uterine cervix in Gabon occurs in young, multiparous women, is diagnosed late and has a poor outcome, hence the interest of prevention. In addition, the reproducibility of the IP should be reevaluated by additional studies. Keywords : adénocarcinoma- clinico pathological aspects- uterine cervix Gabon
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".