Comparison of amyloid burden in individuals with Down syndrome versus autosomal dominant Alzheimer's disease: a cross-sectional study
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
No Canadian affiliation. An affiliation-only frame, the usual design, would never have seen this work. It is one of the works that make the case for inverting the frame.
Full frame distilled prediction
Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
- Candidate categories
- Insufficient payload (model declined to judge)
- Consensus categories
- none
- Domain
- Candidate signal: noneConsensus signal: none
- Study design
- Candidate signal: ObservationalConsensus signal: Observational
- Genre
- Candidate signal: EmpiricalConsensus signal: Empirical
- Teacher disagreement score
- 0.011
- Threshold uncertainty score
- 0.999
- Validation status
machine_predicted_unvalidated·codex-gemma-dda1882f352a
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
- Teacher spread
- 0.295 · how far apart the two teachers sit on this one work
- Validation status
score_only:v0-immature-baseline· verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
Abstract
No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.
The record
- Venue
- The Lancet Neurology
- Topic
- Down syndrome and intellectual disability research
- Field
- Medicine
- Canadian institutions
- not available
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNational Institute of Child Health and Human DevelopmentNIHR Cambridge Biomedical Research CentreInstituto de Salud Carlos IIIFonds de Recherche du Québec - SantéNational Institutes of HealthUK Dementia Research InstituteFleniDeutsches Zentrum für Neurodegenerative ErkrankungenEisaiUniversity of OxfordDepartment of Health and Social CareKorea Health Industry Development InstituteNational Institute on AgingNational Institute for Health and Care ResearchCanadian Institutes of Health ResearchFoundation for Barnes-Jewish HospitalJapan Agency for Medical Research and DevelopmentGHR FoundationFondation Brain CanadaU.S. Department of DefenseEli Lilly and CompanyBrightFocus FoundationHope Center for Neurological DisordersAlzheimer's AssociationBiogenAutism SpeaksUniversity College London Hospitals NHS Foundation Trust
- Keywords
- PSEN1Down syndromeAlzheimer's diseaseMedicinePresenilinApolipoprotein EPittsburgh compound BAmyloid (mycology)Amyloid precursor proteinDiseaseBiomarkerDementiaInternal medicinePathologyOncologyGeneticsBiologyPsychiatry
- Has abstract in OpenAlex
- no