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Record W4312229316 · doi:10.1039/9781839166990-00181

Volatile Signatures of the Microbiome

2022· book-chapter· en· W4312229316 on OpenAlexaff
R. Naddaf, Rachel Herren, N. Geva-Zatorsky

Bibliographic record

Venuenot available
Typebook-chapter
Languageen
FieldEngineering
TopicAdvanced Chemical Sensor Technologies
Canadian institutionsPrincess Margaret Cancer CentreCanadian Institute for Advanced Research
Fundersnot available
KeywordsMicrobiomeMulticellular organismHost (biology)BiologyHuman microbiomeNicheHuman healthGut microbiomeComputational biologyEvolutionary biologyEcologyBioinformaticsGeneticsGeneMedicine

Abstract

fetched live from OpenAlex

Microbiomes are niche ecosystems found on and within eukaryotic hosts. Interactions between microbiomes and their multicellular hosts are numerous, many of them being mediated or influenced by volatile organic compounds (VOCs). The relationships between the human microbiome and host physiology, health and disease have been extensively studied, yet mechanistic and molecular understanding remains lacking. To date, only a few of microbial-derived molecules are characterized as mediators of microbe–host communications. While bacteria produce a variety of VOCs with chemical characteristics that allow unique communications with the host, the human gut microbiome VOC profile has not yet been fully explored. In this chapter, we summarize a few examples of molecules that have been studied as communication mediators between the microbiome and the host and that are recognized as VOCs. The goal is to stress the importance of microbial VOC-specific research as a new and unexplored field of research with high potential.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesInsufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Other · Consensus signal: Other
Teacher disagreement score0.634
Threshold uncertainty score0.998

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0030.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.006
GPT teacher head0.171
Teacher spread0.165 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designBench or experimental
Domainnot available
GenreOther

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2022
Admission routes1
Has abstractyes

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