Dynamics of matrix metalloproteinases when correcting immature hypertrophic scars with pulsed dye laser and fermencol phonophoresis
Bibliographic record
Abstract
The article analyzes the role of matrix metalloproteinases (MMP) in the pathogenesis of immature hypertrophic scars. The revealed decrease in the MMP level in the patients’ initial state against the background of an increased content of TIMP1 indicates a disorder in the mechanisms of regulation of collagen formation in a hypertrophic scar, as a result of which its synthesis significantly predominates over decay, contributing to the formation of a fibrous process. The obtained results convincingly prove that reduced expression of MMP against the background of an increased TIMP1 level is an important pathogenetic mechanism providing excessive deposition of extracellular matrix components in pathological skin scarring. The use of a pulsed dye laser (PDL) in combination with Fermencol phonophoresis promotes an increase in the MMP content in the blood serum of patients with immature hypertrophic scars. The reliable dynamics of the studied biomarkers indicates an increase in the processes of catabolism of the extracellular matrix components and an increase in the regenerative potential of the skin defect, which determine the intensity of the clinical effect during the treatment of immature hypertrophic scars. The correlation analysis between the level of membrane metalloproteinases and the parameters of the Vancouver Scar Scale revealed a set of significant relationships that confirm the clinical and pathogenetic significance of these biochemical variables in the development of fibroplastic processes and also act as informative criteria for the effectiveness of the therapy.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".