The VSVΔG/ZEBOV GP vaccine protects against an Ebola infection and induces humoral and cellular immunity (128.16)
Bibliographic record
Abstract
Abstract Ebola virus (EBOV) is a highly infectious filovirus causing a severe hemorrhagic fever in humans with fatality rates approaching 90%. We used the live attenuated recombinant vaccine vector vesicular stomatitis virus (VSV) to create a vaccine for EBOV. Ten cynomolgus macaques were immunized either intramuscularly (IM), orally (OR), or intranasally (IN) with VSVΔG/ZEBOVGP 28 days before receiving a lethal challenge of Zaire ebolavirus (ZEBOV). There were no signs of illness in the vaccinated animals, and no loss of lymphocytes typically seen during infection. ZEBOVGP-specific humoral and cell mediated immune responses (CMIR) were generated by all immunization routes. Surprisingly, in general, the IN route generated more potent humoral responses, while the IM route generated early IL-2 and IFN-γ CMIR. We demonstrate that a single dose of the VSVΔG/ZEBOVGP vaccine delivered by any of the three routes induces cellular and humoral immune responses and protects non-human primates against a lethal challenge of ZEBOV.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".