Intracisternally localized lupus serum IgG induces meningitis (HUM3P.245)
Bibliographic record
Abstract
Abstract Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by high autoantibody levels and multiorgan tissue damage, including brain. Headache in SLE patients is frequent clinical manifestations and its etiology and pathogenesis remains unclear. We hypothesized that lupus serum containing high levels of IgG induces meningitis. Information from the analyzed 150 lupus patients demonstrates higher levels of IgG in CSF from lupus patients with headache than that without headache. There is meningitis in brain of MRL/lpr mice. We have intracisternally injected mice and rats with serum from patients with SLE, health individuals, lupus prone mice and normal mice , and found meningitis induced only by serum from lupus patients and lupus prone mice. Meningitis induced by lupus serum appeared 12 h and peaked 3 days after injection. Deleted the monocyte/ macrophage abrogated meningitis but lack of lymphocyte did not affect the development of meningitis induced by lupus serum. Specific interactions with vascular selectin expression and depletion of complement system led to a significant amelioration of meningitis. Depletion of IgG from lupus serum reduced meningitis suggests that IgG is important contributor in lupus serum-induced meningitis. Intracisternally lupus serum may trigger development of hippocampus neuron apoptosis. This study proves that lupus serum IgG induces meningitis, which is important mechanism of headache of lupus patients.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".