Combinations of inhibitory receptors are expressed on CD8+ T cells in pediatric subjects following bone marrow or umbilical cord blood transplantation. (P2162)
Bibliographic record
Abstract
Abstract Umbilical cord blood transplantation (UCBT) is commonly used to treat a variety of hematologic or neoplastic disorders in children. Compared to bone marrow transplantation (BMT), UCBT is associated with slow engraftment and a higher incidence of graft failure and opportunistic infections. The aim of the present study was to identify immunologic biomarkers expressed by CD8+ T cells during the post-transplant period that predispose patients to develop complications following UCBT or BMT. Pediatric patients who underwent UCBT (n=16) or BMT (n=7) were enrolled at CHU Sainte-Justine. Samples were obtained from graft inoculums and from transplanted subjects during 24 months of follow-up. Expression of inhibitory receptors associated with CD8+ T cell exhaustion (PD-1, CTLA-4, 2B4, TIM-3, BTLA-4, LAG-3) was studied ex vivo using multiparameter flow cytometry. Results showed that inhibitory receptors were expressed at very low levels in UCB graft inoculums. However, in the first 100 days after UCBT or BMT, a notable increase in the frequency PD-1+ CD8+ T cells and 2B4+ CD8+ T cells was observed, and frequencies of PD-1+ and 2B4+ T cells were inversely correlated with absolute CD8+ T cell counts. A low number of CD8+ T cells also co-expressed two or more inhibitory receptors. These results suggest that expression of exhaustion markers by CD8+ T cells in graft recipients during the early post-transplant period may modulate their activity and lead to functional impairment.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".