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Record W4313426608 · doi:10.1101/2022.12.28.522087

Forces driving transposable element load variation during Arabidopsis range expansion

2022· preprint· en· W4313426608 on OpenAlexfundno aff
Juan Jiang, Yong‐Chao Xu, Zhiqin Zhang, Jia‐Fu Chen, Xiao‐Min Niu, Xinghui Hou, Xintong Li, Lı Wang, Yong E. Zhang, Song Ge, Ya‐Long Guo

Bibliographic record

VenuebioRxiv (Cold Spring Harbor Laboratory) · 2022
Typepreprint
Languageen
FieldAgricultural and Biological Sciences
TopicChromosomal and Genetic Variations
Canadian institutionsnot available
FundersInstitute of Botany, Chinese Academy of SciencesInstitute of Genetics and Developmental Biology, Chinese Academy of SciencesChinese Academy of SciencesInstitute of Zoology, Chinese Academy of SciencesInstitute of GeneticsNational Natural Science Foundation of China
KeywordsGenetic loadTransposable elementBiologyGenetic variationRange (aeronautics)PopulationTransposition (logic)ArabidopsisArabidopsis thalianaNatural selectionEvolutionary biologyGeneticsGeneGenomeMutantInbreedingComputer scienceEngineering

Abstract

fetched live from OpenAlex

ABSTRACT Genetic load refers to the accumulated and potentially life-threatening deleterious mutations in populations. Understanding the mechanisms underlying genetic load variation of transposable elements (TEs), one major large-effect mutations, during range expansion is an intriguing question in biology. Here, we used 1,115 globally natural accessions of Arabidopsis thaliana , to study the driving forces of TE load variation during its range expansion. The TE load increased with range expansion, especially in the recently established Yangtze River basin population. The effective population size explained 62.0% of the variance in TE load, and high transposition rate and positive selection or hitch-hiking effect contributed to the accumulation of TEs in the expanded populations. We genetically mapped the candidate causal genes or TEs and revealed the genetic architecture of TE load. Overall, this study reveals the variation in the genetic load of TEs during Arabidopsis expansion and highlights the causes of TE load variation.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.001
Threshold uncertainty score0.003

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.012
GPT teacher head0.195
Teacher spread0.184 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations8
Published2022
Admission routes1
Has abstractyes

Explore more

Same venuebioRxiv (Cold Spring Harbor Laboratory)Same topicChromosomal and Genetic VariationsFrench-language works237,207