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Record W4313893597 · doi:10.3390/zoonoticdis3010002

Canada Lynx (Lynx canadensis) as Potential Reservoirs and Sentinels of Toxoplasma gondii in Northern Canada

2023· article· en· W4313893597 on OpenAlexafffundabout
Émilie Bouchard, Rajnish Sharma, Adrián Hernández‐Ortiz, Thomas S. Jung, N. Jane Harms, Caitlin N. Willier, Rudy Boonstra, Yasmine N. Majchrzak, Michael J. L. Peers, Géraldine-G. Gouin, Batol Al‐Adhami, Audrey Simon, Patrick A. Leighton, Emily Jenkins

Bibliographic record

VenueZoonotic Diseases · 2023
Typearticle
Languageen
FieldImmunology and Microbiology
TopicToxoplasma gondii Research Studies
Canadian institutionsCanadian Food Inspection AgencyMemorial University of NewfoundlandThe Scarborough HospitalMakivik CorporationUniversity of TorontoCentre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-MontréalYukon Department of EnvironmentUniversity of AlbertaUniversité de MontréalUniversity of Saskatchewan
FundersArcticNetPolar Knowledge CanadaNatural Sciences and Engineering Research Council of CanadaCanadian Food Inspection Agency
KeywordsToxoplasma gondiiFecesBiologyParasite hostingZoologyToxoplasmosisWildlifeEcologyAntibodyVirologyImmunology

Abstract

fetched live from OpenAlex

Toxoplasma gondii is a zoonotic parasite globally infecting a wide range of species, including humans. Felids are the only known hosts that can excrete environmentally resistant oocysts into ecosystems. In boreal regions, Canada lynx (Lynx canadensis) are sought by hunters primarily for their fur, and they are occasionally eaten. We examined carcasses salvaged from trappers from boreal regions of eastern (n = 97) and western (n = 357) Canada. We detected T. gondii antibodies in fluid from thawed heart tissue using an enzyme-linked immunosorbent assay, DNA in brain and heart via magnetic capture and real-time PCR assay, and presence of DNA in feces using a real-time PCR with melt curve analysis. We detected antibodies against T. gondii and DNA in tissues in 24% and 19% of lynx, respectively. One lynx was positive for DNA of T. gondii in feces, which could indicate intestinal infection and potential for shedding oocysts. Our results indicate that lynx may be a useful sentinel species for monitoring environmental circulation of T. gondii in northern boreal regions and may pose a risk for transmission to other wildlife and to people handling or consuming lynx.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.149
Threshold uncertainty score0.928

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.007
GPT teacher head0.218
Teacher spread0.211 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations13
Published2023
Admission routes3
Has abstractyes

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