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Record W4315928450 · doi:10.1093/rheumatology/keac713

An international survey of current management practices for polymyalgia rheumatica by general practitioners and rheumatologists

2023· article· en· W4315928450 on OpenAlexaff
Agnete Overgaard Donskov, Sarah Mackie, Ellen‐Margrethe Hauge, Carlos Enrique Toro Gutiérrez, Ib Tønder Hansen, Andrea Katharina Hemmig, Aatke van der Maas, Tamer A. Gheita, Berit Dalsgaard Nielsen, Karen Douglas, Richard Conway, Elena Rezuş, Bhaskar Dasgupta, Sara Monti, Eric L. Matteson, Sebastian E. Sattui, Mark Matza, Vanessa Ocampo, Margarita Aleksandrovna Gromova, Rebecca Grainger, Andrea Bran, Simone Appenzeller, Annelise Goecke, Nelly Colmán, Helen Keen, Masataka Kuwana, Latika Gupta, Babur Salim, Ghita Harifi, M. Erraoui, Nelly Ziadé, Nizar Abdulateef Al-Ani, Adeola Ajibade, Johannes Knitza, Line L. Frølund, Max Yates, Víctor R. Pimentel-Quiroz, André Marun Lyrio, Maria Sandovici, Kornelis S. M. van der Geest, Toby Helliwell, Elisabeth Brouwer, Christian Dejaco, Kresten Krarup Keller

Bibliographic record

VenueLara D. Veeken · 2023
Typearticle
Languageen
FieldMedicine
TopicVasculitis and related conditions
Canadian institutionsToronto Western Hospital
FundersChugai PharmaceuticalRegion MidtjyllandSwedish Orphan BiovitrumNovo Nordisk FondenAstellas PharmaNordic Pharma GroupOno PharmaceuticalEisaiArgenxGigtforeningenKisseiAarhus UniversitetshospitalSanofiAarhus UniversitetAbbVieNational Institute for Health and Care ResearchStiftung für die Erforschung der MuskelkrankheitenPfizerRheumatology Research FoundationCelgeneAstraZenecaEli Lilly and Company
KeywordsPolymyalgia rheumaticaMedicineFamily medicineInternal medicineMedical educationPhysical therapyMedical physicsGiant cell arteritisDisease

Abstract

fetched live from OpenAlex

OBJECTIVES: To explore current management practices for PMR by general practitioners (GPs) and rheumatologists including implications for clinical trial recruitment. METHODS: An English language questionnaire was constructed by a working group of rheumatologists and GPs from six countries. The questionnaire focused on: 1: Respondent characteristics; 2: Referral practices; 3: Treatment with glucocorticoids; 4: Diagnostics; 5: Comorbidities; and 6: Barriers to research. The questionnaire was distributed to rheumatologists and GPs worldwide via members of the International PMR/Giant Cell Arteritis Study Group. RESULTS: In total, 394 GPs and 937 rheumatologists responded to the survey. GPs referred a median of 25% of their suspected PMR patients for diagnosis and 50% of these were returned to their GP for management. In general, 39% of rheumatologists evaluated patients with suspected PMR >2 weeks after referral, and a median of 50% of patients had started prednisolone before rheumatologist evaluation. Direct comparison of initial treatment showed that the percentage prescribing >25 mg prednisolone daily for patients was 30% for GPs and 12% for rheumatologists. Diagnostic imaging was rarely used. More than half (56%) of rheumatologists experienced difficulties recruiting people with PMR to clinical trials. CONCLUSION: This large international survey indicates that a large proportion of people with PMR are not referred for diagnosis, and that the proportion of treatment-naive patients declined with increasing time from referral to assessment. Strategies are needed to change referral and management of people with PMR, to improve clinical practice and facilitate recruitment to clinical trials.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.007
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.007
Threshold uncertainty score0.014

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0030.007
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.002
Science and technology studies0.0000.000
Scholarly communication0.0000.001
Open science0.0000.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.044
GPT teacher head0.365
Teacher spread0.321 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations44
Published2023
Admission routes1
Has abstractyes

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