Pemphigoid nodularis – diagnostic challenges
Bibliographic record
Abstract
Introduction: Bullous pemphigoid is an autoimmune bullous disease that occurs most often in old age.The nodular form of pemphigoid may mimic other dermatoses, but also coexist with them, which causes diagnostic and therapeutic difficulties.Case reports: We present cases of two women (81-year-old and 67-year--old) with a several year history of polymorphic lesions who were initially diagnosed as nodular prurigo.At that time both patients were treated with phototherapy with good tolerance and improvement.During the next courses of UVB-NB irradiation, the condition of their skin deteriorated significantly.Direct immunofluorescence and indirect immunofluorescence studies identified pemphigoid.The initiated pharmacological treatment with methotrexate and systemic glucocorticosteroids resulted in a significant clinical improvement.Conclusions: Presented cases draw attention to the atypical clinical presentation and the impact of UVB-NB phototherapy on the appearance of the first symptoms of pemphigoid.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.005 | 0.022 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.004 | 0.001 |
| Science and technology studies | 0.001 | 0.002 |
| Scholarly communication | 0.003 | 0.008 |
| Open science | 0.002 | 0.002 |
| Research integrity | 0.005 | 0.011 |
| Insufficient payload (model declined to judge) | 0.009 | 0.010 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".