Controlled Chitosan Molecular Weight Reduction by Mechanochemical and Aging-based Phosphoric Acid Hydrolysis
Bibliographic record
Abstract
Chitosan is typically produced by the deacetylation of biopolymer chitin. Its molecular weight (Mw) is a function of the chitin source and the deacetylation conditions. It remains a challenge to both control the Mw of chitosan and obtain good polydispersity, essential for optimal function of chitosan in different applications. This study explores the use of mechanochemistry and aging as effective methods towards the controlled reduction of the Mw of commercial high Mw chitosan (HMwChs) with phosphoric acid where Mw was measured by gel permeation chromatography (GPC). In comparison to conventional solution-based methods, this new mechanochemical process features improved process mass intensity in comparison to conventional techniques and affords low Mw chitosan (LMwChs) samples in a range of 200 to as low as 19.5 kDa, with a polydispersity of 1.8.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".