Association between genetic variants in key vitamin‐D‐pathway genes and external apical root resorption linked to orthodontic treatment
Bibliographic record
Abstract
Abstract This study evaluated the association between single‐nucleotide polymorphisms (SNPs) in vitamin‐D‐related genes and the amount of external apical root resorption linked to orthodontic treatment. One hundred and forty‐three individuals were assessed. The amount of external apical root resorption of upper central incisors (EARR inc ) and lower first molars (EARR mol ) were evaluated in radiographs. Seven SNPs were genotyped across four genes including the vitamin D receptor [ VDR ], group‐specific component [ GC ], cytochrome P450 family 27 subfamily B member 1 [ CYP27B1 ], and cytochrome P450 family 24 subfamily A member 1 [ CYP24A1 ]. Linear regressions were implemented to determine allele‐effects on external apical root resorption. Individuals carrying the AA genotype in VDR rs2228570 had a 21% higher EARR mol than those having AG and GG genotypes (95% CI: 1.03,1.40). EARR mol in heterozygous rs2228570, was 12% lower than for homozygotes (95%CI: 0.78,0.99). Participants with the CCG haplotype (rs1544410‐rs7975232‐rs731236) in VDR had an EARR mol 16% lower than those who did not carry this haplotype. Regarding CYP27B1 rs4646536, EARR inc in participants who had at least one G allele was 42% lower than for homozygotes AA (95%CI: 0.37,0.93). Although these results did not remain significant after multiple testing adjustment, potential associations may still be suggested. Further replication studies are needed to confirm or refute these findings.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".