Nanoscale organization of phosphoinositide signaling in the plasma membrane?
Bibliographic record
Abstract
Organization of cellular membranes at the nanoscale is a topic of central importance for cell biology.Most of us can fondly recall colorful artistic renderings of the plasma membrane (PM) encountered as students, depicting an organized lipid bilayer and attendant protein and carbohydrate components.These images and the fluidic mosaic concept of membrane dynamics easily captures the imagination, but the truth is that much remains speculative about the organization and dynamics of membrane components at the nanoscale.Nowhere is this black box more evident (and important) than in cellular signal transduction, where transmembrane receptor engagement triggers modifications of lipids in the inner leaflet of the PM that occur over tiny scales of time and distance.The organization of transiently-modified lipids and proteins in space and over time is likely a key component of the specificity in signaling cascades, where so many of the major players are ubiquitous and multi-functional.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.002 | 0.002 |
| Scholarly communication | 0.002 | 0.002 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.007 | 0.005 |
| Insufficient payload (model declined to judge) | 0.004 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".