Effect of Piperine on Diameter of Graafian Follicles of Adult Female Albino Rats
Bibliographic record
Abstract
Background: Piperine is an alkaloid present in black pepper. It causes increase in diameter of Graafian follicles when given to adult female albino rats thus leading to decreased fertility. Aim: To assess the harmful effects of piperine on ovaries of adult female albino rats on diameter of Graafian follicles. Study design: Experimental Study. Place and duration of study: Anatomy Department, Shaikh Zayed PGMI, Lahore from 1st August 2013 to 31st January 2014. Methodology: Thirty female rats were randomly separated into three equal groups A, B and C, each having 10 animals. Group A was control and did not receive any medication except for normal saline at a dose of 10ml/kg body weight/day by orogastric tube for 30 days. Group B and C received piperine suspended in saline by orogastric tube, at a dose of5mg/kg/day and 10 mg/kg/day respectively for 30 days. After 30 days of experiment, the rats of all three groups were euthanized and ovaries were removed by dissection and then fixed in 10% formalin. With rotary microtome, 4-5μm sections were prepared and stained with hematoxylin and eosin solutions. Results: The Graafian follicle in ovaries of rats in group B showed increased diameter as compared to control group A. The diameter of Graafian follicles of group C was greater than of group B. In both groups comparison was made, the p-value was less than 0.001. Conclusion: Piperine administration in female adult albino rats showed significant increase in size of Graafian follicle which is likely to produce polycystic ovarian syndrome (PCOS) and in this way hamper fertility in females during child bearing age. Keywords: Piperine, Albino rat, Ovaries, Fertility, Polycystic ovarian syndrome (PCOS)
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".