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Record W4319603665 · doi:10.31080/asgis.2023.06.0512

Intestinal Adenocarcinoma in Biopsy-Defined Celiac Disease

2023· article· en· W4319603665 on OpenAlexaff
Hugh James Freeman

Bibliographic record

VenueActa Scientific Gastrointestinal Disorders · 2023
Typearticle
Languageen
FieldMedicine
TopicCeliac Disease Research and Management
Canadian institutionsUniversity of British Columbia
Fundersnot available
KeywordsBiopsyMedicineAdenocarcinomaDiseaseGastroenterologyInternal medicinePathologyCancer

Abstract

fetched live from OpenAlex

Different intestinal malignancies develop in celiac disease, particularly lymphoma. In this study, the records of 154 patients with celiac disease followed during a 30 year period with an initial small bowel biopsy and a histopathological response to a gluten-free diet were retrospectively reviewed for development of adenocarcinoma. Four males were observed with a small bowel adenocarcinoma as well as 1 elderly female with colon cancer. Other sites, including esophagus, stomach, hepatobiliary tract and pancreas, had no adenocarcinomas detected. Patients with biopsy-defined celiac disease had an increased rate of small bowel adenocarcinoma, at least in males, but a reduced rate of colonic adenocarcinoma. These long-term clinical results from published studies in a well-defined population of celiac disease have important implications for further investigative endeavour related to celiac disease and intestinal malignancies.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.002
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow), Insufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.049
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.003
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.022
GPT teacher head0.282
Teacher spread0.260 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2023
Admission routes1
Has abstractyes

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