Measurement error correction in mediation analysis under the additive hazards model
Bibliographic record
Abstract
In the disciplines of medicine, biology and social science, causal mediation analysis is widely used to examine the effect of an exposure on an outcome through different causal pathways. Recently, there is rapid development of mediation analysis with survival data. An early work of Lange and Hansen proposed to identify the direct and indirect causal effects under the additive hazards model with a single mediator. However, inaccurate measurements of mediators and confounders may lead to biased causal effect estimation. We propose a measurement error correction approach to tackle measurement error in the mediators and confounders under the additive hazards model where multiple mediators are present. We apply the proposed corrected method to the ACTG175 Study data set, and uncover interesting findings.
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How this classification was reachedexpand
Direct model labels (unvalidated)
Per-model category and study-design labels from the labeling rounds. They are machine output, unvalidated, and the disagreement between models ships as data. No study design here is MEDLINE-validated yet.
| Model arm | Categories | Study design | Confidence |
|---|---|---|---|
| gpt | no category Domain: not available · Genre: Methods About the Canadian research system: no · About a Canadian topic: no | Theoretical or conceptual | low |
| grok | no category Domain: not available · Genre: Methods About the Canadian research system: no · About a Canadian topic: no | Theoretical or conceptual | low |
| opus | no category Domain: not available · Genre: Methods About the Canadian research system: no · About a Canadian topic: no | Simulation or modeling | low |
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.133 | 0.330 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.003 | 0.004 |
| Bibliometrics | 0.003 | 0.005 |
| Science and technology studies | 0.002 | 0.005 |
| Scholarly communication | 0.002 | 0.004 |
| Open science | 0.005 | 0.005 |
| Research integrity | 0.003 | 0.006 |
| Insufficient payload (model declined to judge) | 0.006 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedLabeled directly by 3 models reading the full record.
The models disagree on parts of this classification; every voice is preserved in the section at the end of the page.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".