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Record W4319863834 · doi:10.51782/jfmo.v6i2.178

Des «nanotransporteurs» d’ADN : Repousser les limites des Nanomédicaments pour traiter le cancer

2023· article· fr· W4319863834 on OpenAlexaboutno aff
CHIKH Djawad

Bibliographic record

VenueJournal de la faculté de médecine d Oran · 2023
Typearticle
Languagefr
FieldMaterials Science
TopicNanoparticle-Based Drug Delivery
Canadian institutionsnot available
Fundersnot available
KeywordsMedicineGynecologyMolecular biologyBiology

Abstract

fetched live from OpenAlex

Une nouvelle classe de transporteurs de médicaments fabriqués avec de l’ADN, qui pourrait améliorer de façon importante le traitement des cancers et d’autres maladies, a été conçue et validée par une équipe de chercheur de l’université de Montréal. Contrairement aux nano-véhicules artificiels actuels (liposomes…), où la concentration de médicament libéré dans le temps par ces véhicules peut varier grandement d’un patient à l’autre, ces transporteurs moléculaires d’ADN peuvent être programmés pour délivrer et maintenir une dose thérapeutique optimale de médicaments dans le sang tout au long du traitement, ce qui les rend plus efficaces et plus précis.Les tests effectués sur des cellules et des modèles animaux se révèlent prometteurs pour deux applications de ces nanotransporteurs d’ADN : l’une contenant la Quinine, un antipaludéen, et l’autre contenant la Doxorubicine, un antibiotique cytotoxique anthracyclinique couramment employé pour traiter le cancer du sein et la leucémie

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.004
Threshold uncertainty score0.007

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0010.001
Open science0.0000.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.036
GPT teacher head0.301
Teacher spread0.266 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2023
Admission routes1
Has abstractyes

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Same venueJournal de la faculté de médecine d OranSame topicNanoparticle-Based Drug DeliveryFrench-language works237,207