Rapid ultraviolet photoacoustic remote sensing microscopy using voice-coil stage scanning
Bibliographic record
Abstract
There is an unmet need for fast virtual histology technologies that exhibit histological realism and can scan large sections of fresh tissue within intraoperative time-frames. Ultraviolet photoacoustic remote sensing microscopy (UV-PARS) is an emerging imaging modality capable of producing virtual histology images that show good concordance to conventional histology stains. However, a UV-PARS scanning system that can perform rapid intraoperative imaging over mm-scale fields-of-view at fine resolution (<500 nm) has yet to be demonstrated. In this work, we present a UV-PARS system which utilizes voice-coil stage scanning to demonstrate finely resolved images for 2×2 mm 2 areas at 500 nm sampling resolution in 1.33 minutes and coarsely resolved images for 4×4 mm 2 areas at 900 nm sampling resolution in 2.5 minutes. The results of this work demonstrate the speed and resolution capabilities of the UV-PARS voice-coil system and further develop the potential for UV-PARS microscopy to be employed in a clinical setting.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".