Comparison of Carbetocin as a Bolus or Infusion With Prophylactic Phenylephrine on Maternal Heart Rate During Cesarean Delivery Under Spinal Anesthesia: A Double-Blinded Randomized Controlled Trial
Bibliographic record
Abstract
( Can J Anesth / J Can Anesth. 2022:69:715–725) Carbetocin is used in elective cesarean deliveries to reduce the risk of postpartum hemorrhage, and the current practice is to administer the drug as a bolus injection. Side effects of carbetocin include low blood pressure and elevated or irregular heart rate. For some patients, this may lead to hemodynamic alterations and raises the question of potential benefits to heart rate and other hemodynamic factors by administering carbetocin via a 10-minute infusion. This study compared a bolus injection to a 10-minute infusion, both with a prophylactic infusion of phenylephrine, to understand if there are significant and clinically applicable differences in heart rate. This study primarily examined variation in heart rate within 20 minutes of drug administration, but also examined other hemodynamic factors such as blood pressure and stroke volume.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.004 | 0.001 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".