Severe rhabdomyolysis temporally associated with SARS-CoV-2 vaccine in an adolescent: a case report
Bibliographic record
Abstract
Background: Rhabdomyolysis has been reported following common vaccines such as influenza vaccines. It has now more recently been temporally associated with SARS-CoV-2 vaccine administration in adults. To our knowledge, there are no published reports of severe rhabdomyolysis temporally associated with SARS-CoV-2 vaccine administration in children. Case Description: We report a case of severe rhabdomyolysis occurring in a 16-year-old previously healthy female, following receipt of the second dose of the Pfizer/BioNTech SARS-CoV-2 vaccine without any other identifiable triggers on history, physical examination, and laboratory investigations. This patient’s creatinine kinase (CK) peaked at 246,900 U/L, at about 90 hours post-vaccination. The patient was hospitalized and treated successfully with intravenous hyperhydration over a 3-day hospital admission with subsequent complete recovery. Conclusions: This is the first pediatric report of rhabdomyolysis temporally associated with administration of the SARS-CoV-2 vaccine. This patient’s full recovery followed a brief hospitalization for hyperhydration. While causality cannot be assigned to this single event, reporting of such adverse events following SARS-CoV-2 vaccination in the pediatric populations is important to create awareness, and to ensure continued post-licensure surveillance of COVID-19 vaccines. The benefits of these vaccines in reducing hospitalizations and deaths, however, continue to outweigh any potential risk of rare adverse events.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.003 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".