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Record W4323050121 · doi:10.1038/s41531-023-00472-6

The IPDGC/GP2 Hackathon - an open science event for training in data science, genomics, and collaboration using Parkinson’s disease data

2023· article· en· W4323050121 on OpenAlexaff
Hampton L. Leonard, Ruqaya Murtadha, Alejandro Martínez-Carrasco, Alina Jama, Amica Corda Müller-Nedebock, Ana Luisa Gil-Martínez, Anastasia Illarionova, Anni Moore, Bernabé I. Bustos, Bharati Jadhav, Brook Huxford, Catherine S. Storm, Clodagh Towns, Dan Vitale, Devina Chetty, Eric Yu, Francis P. Grenn, Gabriela Salazar, Geoffrey Rateau, Hirotaka Iwaki, Inas Elsayed, Isabelle F. Foote, Zuné Jansen van Rensburg, Jonggeol Jeff Kim, Jie Yuan, Julie Lake, Kajsa Brolin, Konstantin Senkevich, Lesley Wu, Manuela Tan, María Teresa Periñán, Mary B. Makarious, Michael Ta, Nikita Simone Pillay, Oswaldo Lorenzo‐Betancor, Paula Reyes‐Pérez, Pilar Álvarez Jerez, Prabhjyot Saini, Rami Al‐Ouran, Ramiya Sivakumar, Raquel Real, Regina H. Reynolds, Ruifneg Hu, Shameemah Abrahams, Shilpa C. Rao, Tarek Antar, Thiago Peixoto Leal, Vassilena Iankova, William J. Scotton, Yeajin Song, Andrew Singleton, Mike A. Nalls, Sumit Dey, Sara Bandrés‐Ciga, Cornelis Blauwendraat, Alastair J. Noyce

Bibliographic record

Venuenpj Parkinson s Disease · 2023
Typearticle
Languageen
FieldEngineering
TopicBiomedical and Engineering Education
Canadian institutionsMcGill UniversityMontreal Neurological Institute and Hospital
FundersNational Institute on AgingVerily Life SciencesCelgenePfizerNational Institutes of HealthU.S. Department of Health and Human ServicesNational Institute of Neurological Disorders and StrokeBarts CharitySanofiMichael J. Fox Foundation for Parkinson's ResearchFoundation for the National Institutes of Health
KeywordsOpen scienceDiseaseGenomicsEvent (particle physics)Data scienceComputer scienceNeurosciencePsychologyMedicineBiologyGeneInternal medicineGeneticsGenome

Abstract

fetched live from OpenAlex

Open science and collaboration are necessary to facilitate the advancement of Parkinson's disease (PD) research. Hackathons are collaborative events that bring together people with different skill sets and backgrounds to generate resources and creative solutions to problems. These events can be used as training and networking opportunities, thus we coordinated a virtual 3-day hackathon event, during which 49 early-career scientists from 12 countries built tools and pipelines with a focus on PD. Resources were created with the goal of helping scientists accelerate their own research by having access to the necessary code and tools. Each team was allocated one of nine different projects, each with a different goal. These included developing post-genome-wide association studies (GWAS) analysis pipelines, downstream analysis of genetic variation pipelines, and various visualization tools. Hackathons are a valuable approach to inspire creative thinking, supplement training in data science, and foster collaborative scientific relationships, which are foundational practices for early-career researchers. The resources generated can be used to accelerate research on the genetics of PD.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.025
metaresearch head score (Gemma)0.040
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesOpen science
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Other · Consensus signal: none
Teacher disagreement score0.997
Threshold uncertainty score0.291

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0250.040
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0030.002
Science and technology studies0.0070.004
Scholarly communication0.0100.008
Open science0.0030.028
Research integrity0.0040.011
Insufficient payload (model declined to judge)0.0870.030

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.108
GPT teacher head0.360
Teacher spread0.252 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

Study designNot applicable
Domainnot available
GenreOther

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations8
Published2023
Admission routes1
Has abstractyes

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