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Record W4323920691 · doi:10.1002/alz.13025

The Nairobi Declaration—Reducing the burden of dementia in low‐ and middle‐income countries (LMICs): Declaration of the 2022 Symposium on Dementia and Brain Aging in LMICs

2023· article· en· W4323920691 on OpenAlex
Gladys E. Maestre, Maria Carrillo, Raj N. Kalaria, Daisy Acosta, Larry Adams, Thierry Adoukonou, Kazeem Akinwande, Joshua Akinyemi, Rufus Akinyemi, Onoja Akpa, Suvarna Alladi, Ricardo Allegri, Raúl L. Arizaga, Faheem Arshad, Oyedunni Arulogun, David Oluwasayo Babalola, Olusegun Baiyewu, Thomas H. Bak, Tarek Bellaj, Judith Boshe, Carol Brayne, David K. Brodie‐Mends, Richard Brown, Jennifer Cahn, Cyrille Nkouonlack, Albertino Damasceno, Ranil de Silva, Rohan de Silva, Mamuka Djibuti, Anna J. Dreyer, Ratnavalli Ellajosyula, Temitope Farombi, Bernard Fongang, Stefânia Forner, Robert P. Friedland, Noe Garza, Antoine Gbessemehlan, Eliza Georgiou, Riadh Gouider, Ishtar Govia, Lea T. Grinberg, Maëlenn Guerchet, Seid Ali Gugssa, Joy Louise Gumikiriza‐Onoria, Deborah Gustafson, Eef Hogervorst, Michael Hornberger, Agustín Ibáñez, Masafumi Ihara, Ozama Ismail, Thomas Gregor Issac, Linus Jönsson, Celestin Kaputu, Wambūi Karanja, Jackline Karungi, Désiré Tshala-Katumbay, Brian W. Kunkle, Joseph H. Lee, Iracema Leroi, Raphaella Lewis, Gill Livingston, Francisco Lopera, Kamada Lwere, Facundo Manes, Lingani Mbakile‐Mahlanza, Pedro Mena, Bruce L. Miller, Athanase Millogo, Abdul Mohamed, Christine Musyimi, Victoria Mutiso, Noeline Nakasujja, David M. Ndetei, Sam Nightingale, Alfred K. Njamnshi, Gabriela Novotni, Primrose Nyamayaro, Solomon Nyame, Julius A Ogeng’o, Adesola Ogunniyi, Maira Okada de Oliveira, Njideka Okubadejo, Martin Orrell, Akintunde T. Orunmuyi, Mayowa Owolabi, Stella‐Maria Paddick, Margaret A Pericak‐Vance, Zvezdan Pirtošek, Felix Potocnik, Bill Preston, Rema Raman, Kirti Ranchod, Mie Rizig, Mónica Rosselli, Deepa Roy, Upal Kunal Basu Roy, M. Salokhiddinov, Mary Sano, Fred Stephen Sarfo, Claudia L. Satizábal, Diego Sepúlveda‐Falla, Sudha Seshadri, Claire E. Sexton, Ingmar Skoog, Peter St George‐Hyslop, Cláudia Kimie Suemoto, Jeremy A. Tanner, Prekshya Thapa, Kamadore Touré, Valentine Ucheagwu, Chinedu Udeh‐Momoh, Victor Valcour, Jeffery M. Vance, Mathew Varghese, Jaime H. Vera, Richard Walker, Wendy Weidner, Patrice Whitehead Gay, Henrik Zetterberg, Yared Z. Zewde

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueAlzheimer s & Dementia · 2023
Typearticle
Languageen
FieldHealth Professions
TopicAging, Elder Care, and Social Issues
Canadian institutionsUniversity of TorontoOccupational Cancer Research CentreDalhousie University
FundersNational Institute on AgingNational Human Genome Research InstituteAcademy of Medical SciencesNational Institute for Health and Care Research
KeywordsDeclarationDementiaLow and middle income countriesMedicineGerontologyPolitical scienceDiseaseEconomic growthDeveloping countryInternal medicine

Abstract

fetched live from OpenAlex

Delegates of the 2022 Symposium on Dementia and Brain Aging in Low- and Middle-Income Countries, representing over 40 countries, met in Nairobi, Kenya, December 5–9 to highlight advances in dementia prevention, diagnosis, care, and research, as well as explore the future needs of the global community. Dementia poses a major threat to optimal brain health and remains a priority for the demographically ever-changing worldwide population. It incurs substantial individual, societal, and global costs. By 2030, the majority of the 78 million people with dementia will be living in low- and middle-income countries (LMICs). Upon consideration of these grave statistics and new diagnostic paradigms with available prevention and treatment strategies, we, the undersigned delegates of the symposium, including the Organizing Committee and speakers, and the African Dementia Consortium (AfDC), with frontline and lived experience, call upon the global community, including governments, policymakers, international economic forums, health and social care providers, together with private and public research funding agencies, research-focused organizations such as universities, nongovernmental organizations, and technology and pharmaceutical companies, to act as follows: Rethink a global approach to dementia, being more focused on the diversity of underserved and underrepresented populations. Shift the balance of investment further toward LMICs, which bear a high burden, to tackle the challenges and seize opportunities and to mitigate the burden of various forms of dementia, including Alzheimer's disease, vascular dementia, and others, globally. Engage and influence policymakers and advocacy organizations to encourage implementation and evaluation of population-level dementia risk reduction interventions at a more diverse global level. In addition to promoting education, controlling cardiovascular risk, and preventing stroke, seriously consider nutritional factors as well as psychosocial activities for brain health and longevity. Ensure that the health and social care systems are equipped to meet the needs of aging populations in the LMICs as well as low-resource settings in high-income countries (HICs). Support research into more affordable, pragmatic, and effective solutions to improve the quality of life of people living with dementia and reduce the expenses of hospitalization, long-term care, and loss of income and indirect costs resulting from dementia. Equip higher education institutions in HICs and LMICs with the capacity to develop a pipeline of local highly motivated early career researchers (ECRs) to ensure future research will be responsive to local population needs and to leverage opportunities offered by different countries. Ensure a research framework with international collaboration that will unwind the rigid structures in LMICs and encourage young, enthusiastic people to give the best of their potential in their countries, thereby preventing brain drain. We believe that timely intervention to address these goals will bring about significant and sustainable improvements in the prevalence, outcomes, and personal and societal impacts of dementia, resulting in a higher quality of life, better care, and global benefits. Nairobi, Kenya, December 9, 2022 Organizing Committee and Speakers of the 2022 Symposium on Dementia and Brain Aging in Low- and Middle-Income Countries.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.138
Threshold uncertainty score0.971

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0020.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0010.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.034
GPT teacher head0.325
Teacher spread0.291 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it