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Record W4324274072 · doi:10.5114/fpn.2022.124735

The beneficial effect of a probiotic sealing the intestinal barrier on the reduction of metabolic syndrome risk parameters - a case report

2022· article· en· W4324274072 on OpenAlexaboutno aff
Beata Trędzbor, K. Krysta, Marek Krzystanek

Bibliographic record

VenuePharmacotherapy in Psychiatry and Neurology · 2022
Typearticle
Languageen
FieldMedicine
TopicDiet and metabolism studies
Canadian institutionsnot available
Fundersnot available
KeywordsNeurologyProbioticPharmacotherapyMetabolic syndromeMedicineInternal medicineBiologyPsychiatryObesity

Abstract

fetched live from OpenAlex

in preventing cardiovascular consequences.Dysbiosis disrupts the integrity of the intestinal barrier, contributing to general inflammation.This process is associated with metabolic disorders, sugar metabolism and obesity.A case report.A description of a 24-year-old patient suffering from paranoid schizophrenia is presented.Due to the lack of mental state improvement and periods of lack of cooperation, pharmacotherapy was modified many times.Finally, remission was achieved after the use of clozapine with paroxetine.The patient was diagnosed with metabolic syndrome.A probiotic sealing the blood-intestines barrier was added to the treatment.After 3 months of using the probiotic, normalisation of the level of glycemia, total cholesterol, LDL, lowering of the level of insulin, and reduction in the level of insulin resistance were observed.Conclusions.The introduction of a probiotic with properties sealing the blood-intestines barrier to the treatment may result in a reduction in the risk parameters of the metabolic syndrome.It is advisable to conduct further research to confirm the above observations.StreSzczenie Wstęp.Ryzyko zespołu metabolicznego u pacjentów chorujących na schizofrenię jest znacząco wyższe niż w populacji ogólnej.Konsekwencją tego faktu jest skrócenie AbStrAct Introduction.The risk of metabolic syndrome in patients with schizophrenia is significantly higher than in the general population.The consequence of this fact is the shortening of life in this group of patients by as much as 20-25%.The search for methods leading to the reduction of metabolic syndrome risk factors is essential Case report / Opis przypadkuThe beneficial effect of a probiotic sealing the intestinal barrier on the reduction of metabolic syndrome risk parameters -a case report Korzystny wpływ probiotyku uszczelniającego barierę jelitową na obniżenie parametrów ryzyka zespołu metabolicznego -opis przypadku

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Case report · Consensus signal: Case report
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.005
Threshold uncertainty score0.013

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.002
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0020.002
Bibliometrics0.0030.002
Science and technology studies0.0020.001
Scholarly communication0.0020.002
Open science0.0010.001
Research integrity0.0050.004
Insufficient payload (model declined to judge)0.0040.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.014
GPT teacher head0.297
Teacher spread0.283 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designCase report
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

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Citations0
Published2022
Admission routes1
Has abstractyes

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