Implicações cardiovasculares ao paciente acometido pela COVID-19: revisão integrativa
Bibliographic record
Abstract
Objetiva-se identificar as implicações cardiovasculares no paciente adulto acometido pela COVID-19. Trata-se de uma revisão integrativa, buscando-se analisar e sistematizar publicações científicas sobre o tema. A seleção ocorreu nas bases de dados MEDLINE, LILACS, IBECS e BDENF, através do indexador Biblioteca Virtual em Saúde (BVS), com os descritores “Infecções por Coronavírus” e “Doenças Cardiovasculares”. Encontraram-se 617 artigos, sendo 1 duplicado. Estabeleceram-se os critérios de exclusão: teses, dissertações, relatos de casos, estudos de revisão e que não respondessem à questão da pesquisa. Quatorze estudos atenderam aos critérios e demonstraram que pacientes críticos com COVID-19 e doenças cardiovasculares apresentaram risco de mortalidade significativamente maior que pacientes não críticos. Identificaram-se as seguintes implicações cardiovasculares em pacientes com COVID-19: cardiotoxicidade direta mediada pelo vírus, lesão relacionada à hipóxia, tempestade de citocinas imunomediadas, inflamação sistêmica, infecção do pericárdio, apoptose, entre outras. Tal observação subsidia protocolos clínicos que antevejam esta deterioração clínica mais rapidamente. Descritores: Implicações Cardiovasculares, COVID-19, Risco de Mortalidade. Cardiovascular implications for patients affected by COVID-19: integrative review Abstract: The objective is to identify the cardiovascular implications in the adult patient affected by COVID-19. This is an integrative review, seeking to analyze and systematize scientific publications on the subject. The selection took place in the MEDLINE, LILACS, IBECS and BDENF databases, through the Virtual Health Library (BVS) index, with the descriptors “Coronavirus Infections” and “Cardiovascular Diseases”. 617 articles were found, with 1 being duplicated. Exclusion criteria were: theses, dissertations, case reports, review studies and those which did not answer the research question. Fourteen studies met the criteria and demonstrated that critically ill patients with COVID-19 and cardiovascular disease had a significantly higher mortality risk than non-critical patients. The following cardiovascular implications were identified in patients with COVID-19: direct virus-mediated cardiotoxicity, hypoxia-related injury, immune-mediated cytokine storm, systemic inflammation, pericardial infection, apoptosis, among others. The observation supports clinical protocols which anticipate this clinical deterioration more quickly. Descriptors: Cardiovascular Implications, COVID-19, Mortality Risk. Implicaciones cardiovasculares para pacientes afectados por COVID-19: revisión integradora Resumen: El objetivo es identificar las implicaciones cardiovasculares en el paciente adulto infectado por COVID-19. Esta es una revisión integrativa, que busca analizar y sistematizar las publicaciones científicas sobre el tema. La selección se realizó en las bases de datos MEDLINE, LILACS, IBECS y BDENF, a través del índice de la Biblioteca Virtual en Salud (BVS), con los descriptores “Infecciones por Coronavirus” y “Enfermedades Cardiovasculares”. Se encontraron 617 artículos, pero 1 era duplicado. Se establecieron criterios de exclusión: tesis, disertaciones, informes de casos, estudios de revisión y aquellos que no respondieran a la pregunta de investigación. Catorce estudios cumplieron con los criterios y demostraron que los pacientes críticos con COVID-19 y enfermedad cardiovascular tenían un riesgo de mortalidad significativamente mayor que los pacientes no críticos. Se identificaron las siguientes implicaciones cardiovasculares en pacientes con COVID-19: cardiotoxicidad directa mediada por virus, lesión relacionada con hipoxia, tormenta de citocinas inmunomediada, inflamación sistémica, infección pericárdica, apoptosis, entre otras. Tal observación apoya los protocolos clínicos que anticipan más rápidamente este deterioro clínico. Descriptores: Implicaciones Cardiovasculares, COVID-19, Riesgo de Mortalidad.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.012 | 0.037 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.003 |
| Bibliometrics | 0.011 | 0.008 |
| Science and technology studies | 0.001 | 0.002 |
| Scholarly communication | 0.006 | 0.004 |
| Open science | 0.002 | 0.002 |
| Research integrity | 0.002 | 0.003 |
| Insufficient payload (model declined to judge) | 0.006 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".