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Record W4327575325 · doi:10.1016/j.cell.2023.02.023

Single substitution in H3.3G34 alters DNMT3A recruitment to cause progressive neurodegeneration

2023· article· en· W4327575325 on OpenAlexafffund
Sima Khazaei, Carol Chen, Augusto Faria Andrade, Nisha Kabir, Pariya Azarafshar, Shahir M. Morcos, Josiane Alves França, Mariana Lopes, Peder J. Lund, Geoffroy Danieau, Samantha Worme, Lata Adnani, Nadine Nzirorera, Xiao Chen, Gayathri Yogarajah, Caterina Russo, Michele Zeinieh, Cassandra J. Wong, Laura Bryant, Steven Hébert, Bethany Tong, Tianna S. Sihota, Damien Faury, Evan Puligandla, Wajih Jawhar, Veronica Sandy, Mitra Cowan, Emily M. Nakada, Loydie A. Jerome‐Majewska, Benjamin Ellezam, Carolina Cavaliéri Gomes, Jonas Denecke, Davor Lessel, Marie T. McDonald, Carolyn Pizoli, Kathryn R. Taylor, Ben Cocanougher, Elizabeth Bhoj, Anne‐Claude Gingras, Benjamin A. García, Chao Lü, Eric I. Campos, Claudia L. Kleinman, Livia Garzia, Nada Jabado

Bibliographic record

VenueCell · 2023
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicEpigenetics and DNA Methylation
Canadian institutionsLunenfeld-Tanenbaum Research InstituteMount Sinai HospitalUniversité de MontréalMcMaster UniversityCentre Hospitalier Universitaire Sainte-JustineSinai Health SystemMcGill University Health CentreHospital for Sick ChildrenJewish General HospitalUniversity of TorontoMcGill University
FundersNational Institute of General Medical SciencesGarron Family Cancer CentreFonds de Recherche du Québec - SantéNatural Sciences and Engineering Research Council of CanadaFondation Charles-BruneauNational Cancer InstituteUniversity of TorontoConselho Nacional de Desenvolvimento Científico e TecnológicoGovernment of OntarioCanadian Institutes of Health ResearchCompute CanadaCoordenação de Aperfeiçoamento de Pessoal de Nível SuperiorMcGill UniversityMcGill University Health CentreNational Institutes of HealthOntario GenomicsAlex's Lemonade Stand Foundation for Childhood CancerNational Institute of Allergy and Infectious DiseasesCancer Research SocietyGenome CanadaNational Institute on AgingCrohn's and Colitis Foundation
KeywordsBiologyNeurodegenerationHistone H3EpigenomeDNA methylationNeuroinflammationGene silencingHistoneGeneticsEpigeneticsChromatinHistone deacetylaseCell biologyGene expressionGeneImmunology

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.006
Threshold uncertainty score0.020

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0000.001
Bibliometrics0.0010.001
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0060.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.062
GPT teacher head0.308
Teacher spread0.246 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations68
Published2023
Admission routes2
Has abstractno

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