Monoclonal Antibodies in Cancer Immunotherapy
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
The technology of monoclonal antibodies (MABs) was originated from the ideas that how antibodies of the B cells bind to the specific antigens to protect the body against foreign invasion. Nowadays, MABs drugs have been approved for more than 30 targets, they have been considered as one of the first-line immunotherapies which specifically target certain cancers. Due to their exquisite target selectivity and less toxicity, MABs have become the new mainstay of pharmaceutical industry. This review summarizes the history of discovery, basic structure, and in vivo production of the MABs. Meanwhile, this review introduces the basic therapeutic applications, mechanism and working process of MABs, MABs and its targeted cancers, issues with current MABs technology and corresponding methods of improvements are also discussed. Overall, MABs do have broad prospect in the future since its effectiveness of treating cancers with poor prognosis and wide therapeutic applications.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.002 | 0.003 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it