The key piece of the airway remodeling puzzle revealed—LIGHT signaling in the lung
Bibliographic record
Abstract
Asthma is a chronic lung disease that primarily affects the lower respiratory tract in more than 300 million people worldwide.Asthma is often triggered by exposure to certain substances or conditions, such as allergens or cold air.The overreaction to the allergens causes inflammation and narrowing of the airway, which leads to episodic or persistent symptoms including shortness of breath, nocturnal cough, chest tightness, and wheezing.1 The cause of the disease is believed to be a combination of genetic and environmental factors.Asthma can be managed with medications that reduce inflammation and keep the airway open, such as bronchodilators and corticosteroids.However, there is currently no ideal treatment for patients with severe asthma which involves airway remodeling (AR).AR is characterized by long-term modification of the airway structure, including airway smooth muscle hyperplasia, increased inflammatory cell number, and submucosal gland hypertrophy, leading to lung function decline.Thus, understanding the molecular mechanism underlying AR is critical for the development of novel asthma therapeutics.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.001 | 0.003 |
| Scholarly communication | 0.003 | 0.004 |
| Open science | 0.001 | 0.002 |
| Research integrity | 0.002 | 0.007 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".