Manipulating the Manipulator: Genetically modifying T. gondii to degrade rather than produce dopamine could be used to treat symptoms of schizophrenia
Bibliographic record
Abstract
The host manipulating parasite Toxoplasmic gondii causes the vector-borne disease, Toxoplasmosis. During the chronic stage of infection, after cysts formation, the parasites release high levels of tyrosine hydroxylase. This enzyme causes an increase in dopamine levels as it is a known limiting factor of dopamine production. The TgAaaH1 and TgAaaH2 genes found in the T. gondii genome are known to be responsible for this production. Increased dopamine levels have been shown to correlatewithschizophrenic symptoms, such as hallucinations and delusions. The two genes can be removed and replaced with the COMT gene. This gene regulates dopamine levels by degrading dopamine. The genetically modified T. gondii can then be administered to patients who show schizophrenic symptoms but are negative for toxoplasmosis.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".