[Early phase of HHV6 infection: role of IE1 and IE2 proteins].
Bibliographic record
Abstract
Human herpesvirus 6 (HHV6) is an opportunistic pathogen whose infection or reactivation is associated with diseases such as roseola, central nervous system disorders and organ transplant anomalies. Following its entry into the host cell, the virus utilizes the cellular machinery in order to transcribe its genes and insure the replicative cycle progression. HHV-6 can also latently persist in its host. Immediate-early proteins are rapidly expressed upon cell infection. In particular, IE1 and IE2 proteins play an important role in the establishment of infection. IE1 inhibits interferon-b transcription and may participate in the PML nuclear body aggregation induced by the viral infection. IE2 is a strong transactivator of multiple cell and viral promoters, and contributes to the initiation of the replicative cycle. In this review we have synthesized the current body of knowledge pertaining to the immediate early phase of HHV6 infection, including the role of immediate-early proteins in the replicative cycle and during latency, as well as that of the promoter who regulates their expression.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.004 | 0.003 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".