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Record W4362527578 · doi:10.1158/1535-7163.22507303

Supplementary Tables S1-S8 from 17-Hydroxy Wortmannin Restores TRAIL's Response by Ameliorating Increased Beclin 1 Level and Autophagy Function in TRAIL-Resistant Colon Cancer Cells

2023· supplementary-materials· en· W4362527578 on OpenAlexaff
Sheng Dai, Shu Yang, Xin Hu, Wei Sun, Gregory J. Tawa, Wenge Zhu, Aaron D. Schimmer, Chao He, Bingliang Fang, Hongbo Zhu, Wei Zheng

Bibliographic record

Venuenot available
Typesupplementary-materials
Languageen
FieldMedicine
TopicDiet, Metabolism, and Disease
Canadian institutionsPrincess Margaret Cancer Centre
Fundersnot available
KeywordsTable (database)Gene knockdownAutophagyColorectal cancerIC50Cancer researchMedicineOncologyCell cultureCancerInternal medicineChemistryBiologyApoptosisComputer scienceGeneticsBiochemistryData mining

Abstract

fetched live from OpenAlex

Supplementary Table S1. Summary of the antibodies used in experiments; Supplementary Table S2. List of compounds confirmed in the high throughput screening with DLD1-R cells; Supplementary Table S3. BECN1 knockdown re-sensitize DLD1-R cells to TRAIL; Supplementary Table S4. IC50 of TRAIL treatment in each cell line; Supplementary Table S5. 17-HW re-sensitizes multiple colon cancer cell lines to TRAIL; Supplementary Table S6. BECN1 knockdown re-sensitize multiple colon cancer cell lines to TRAIL; Supplementary Table S7. Patient demographics and baseline characteristics; Supplementary Table S8. Clinicopathological factors and their relationship to the expression of beclin1 and caspase-8

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.009
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesInsufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Dataset · Consensus signal: Dataset
Teacher disagreement score0.744
Threshold uncertainty score0.365

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.009
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0020.001
Bibliometrics0.0040.005
Science and technology studies0.0020.000
Scholarly communication0.0020.002
Open science0.0030.001
Research integrity0.0010.002
Insufficient payload (model declined to judge)0.7440.283

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.032
GPT teacher head0.301
Teacher spread0.269 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

Study designNot applicable
Domainnot available
GenreDataset

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2023
Admission routes1
Has abstractyes

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