Time-course proteomic study of Acinetobacter baumannii after exposure to oxidative stress
Bibliographic record
Abstract
Acinetobacter baumannii is an opportunistic nosocomial Gram-negative bacterium responsible for infectious diseases.Due to its rapidly growing multidrug resistance (MDR), there is a need to improve understanding of host-pathogen interactions to identify targets for the development of novel therapeutics.Characterizing bacterial responses to a stress condition representative of a host environment was hypothesized to provide improved understanding of A. baumannii pathogenesis.To this end, an in vitro time-course proteomic study evaluating the impact of oxidative stress on two clinical strains exhibiting different levels of virulence was performed using mass spectrometry.After exposure to hydrogen peroxide, 38 proteins and 181 proteins were observed to have different abundance levels in strain Lac-4 and Lac-5, respectively.The putative localization, pathway and molecular function of these proteins were assessed.Proteins that changed abundance levels were of interest as they indicate potential response to stress and could lead to targets for future therapeutic development.iii
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".