MétaCan
Menu
Back to cohort
Record W4362575266 · doi:10.1016/j.ymthe.2023.03.028

The unfolded protein response transcription factor XBP1s ameliorates Alzheimer’s disease by improving synaptic function and proteostasis

2023· article· en· W4362575266 on OpenAlexfundno aff
Claudia Duran‐Aniotz, Natalia Poblete, Catalina Rivera-Krstulovic, Álvaro O. Ardiles, Mei Li Díaz-Hung, Giovanni Tamburini, Carleen Mae P. Sabusap, Yannis Gerakis, Felipe Cabral‐Miranda, Javier Diaz, Matías Fuentealba, Diego Arriagada, Ernesto Germán Cardona-Muñóz, Sandra Espinoza, Gabriela Martínez, Gabriel Quiroz, Pablo Sardi, Danilo B. Medinas, Darwin Contreras, Ricardo Piña, Mychael V. Lourenco, Felipe C. Ribeiro, Sérgio T. Ferreira, Carlos Rozas, Bernardo Morales, Lars Plate, Christian González‐Billault, Adrián G. Palacios, Claudio Hetz

Bibliographic record

VenueMolecular Therapy · 2023
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicEndoplasmic Reticulum Stress and Disease
Canadian institutionsnot available
FundersAir Force Office of Scientific ResearchFondo de Financiamiento de Centros de Investigación en Áreas PrioritariasFondo de Fomento al Desarrollo Científico y TecnológicoComisión Nacional de Investigación Científica y TecnológicaU.S. Air ForceInstitut de Cardiologie de MontréalFondo Nacional de Desarrollo Científico y TecnológicoInstituto SerrapilheiraAgencia Nacional de Investigación y DesarrolloAlzheimer's AssociationDepartamento de Investigaciones Científicas y Tecnológicas, Universidad de Santiago de ChileConselho Nacional de Desenvolvimento Científico e TecnológicoUniversidad de Santiago de ChileU.S. Department of Defense
KeywordsProteostasisTranscription factorUnfolded protein responseFunction (biology)BiologyDiseaseCell biologyNeuroscienceMedicineEndoplasmic reticulumGeneGeneticsInternal medicine

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.020
Threshold uncertainty score0.669

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.012
GPT teacher head0.240
Teacher spread0.228 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations62
Published2023
Admission routes1
Has abstractno

Explore more

Same venueMolecular TherapySame topicEndoplasmic Reticulum Stress and DiseaseFrench-language works237,207