Bibliographic record
Abstract
In the present thesis, we used a rodent analogous coronavirus, murine hepatitis virus (MHV), in culture to directly assess its impact on astrocytic and microglial cells. Given the increasing importance of the brain neurotrophic factor (BDNF)-TrkB signaling system in glial functioning, we also assessed whether the unique TrkB.T1 truncated isoform (the only BDNF receptor on astrocytes) would modulate glial reactivity to MHV viral infection. Our results largely support the notion that MHV readily infects astrocytes and caused a degree of toxicity of these cells. The addition of microglia to the astrocytic culture modulated the magnitude of this effect and greatly increased pro-inflammatory cytokine release. Furthermore, TrkB.T1 deficiency appeared to greatly reduce astrocyte viability and microglial morphology. These data may have useful implications for better understanding the nature of glial responses to coronaviral infection and the importance of TrkB in such responses.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".