Three-round learning strategy based on 3D deep convolutional GANs for Alzheimer’s disease staging
Bibliographic record
Abstract
Accurately diagnosing of Alzheimer's disease (AD) and its early stages is critical for prompt treatment or potential intervention to delay the the disease's progression. Convolutional neural networks (CNNs) models have shown promising results in structural MRI (sMRI)-based diagnosis, but their performance, particularly for 3D models, is constrained by the lack of labeled training samples. To address the overfitting problem brought on by the insufficient training sample size, we propose a three-round learning strategy that combines transfer learning with generative adversarial learning. In the first round, a 3D Deep Convolutional Generative Adversarial Networks (DCGAN) model was trained with all available sMRI data to learn the common feature of sMRI through unsupervised generative adversarial learning. The second round involved transferring and fine-tuning, and the pre-trained discriminator (D) of the DCGAN learned more specific features for the classification task between AD and cognitively normal (CN). In the final round, the weights learned in the AD versus CN classification task were transferred to the MCI diagnosis. By highlighting brain regions with high prediction weights using 3D Grad-CAM, we further enhanced the model's interpretability. The proposed model achieved accuracies of 92.8%, 78.1%, and 76.4% in the classifications of AD versus CN, AD versus MCI, and MCI versus CN, respectively. The experimental results show that our proposed model avoids overfitting brought on by a paucity of sMRI data and enables the early detection of AD.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".