Effect of hyperbaric oxygen combined with folic acid on clinical efficacy and cognitive function in patients with cerebral small vessel disease.
Bibliographic record
Abstract
OBJECTIVE: To identify the effect of hyperbaric oxygen combined with folic acid on clinical efficacy and cognitive function in patients with cerebral small vessel disease (CSVD), and to analyze the risk factors affecting efficacy. METHODS: Data from 108 elderly patients with CSVD (homocysteine (Hcy) > 10 μmol/L) treated in The First Hospital of Yulin from February 2019 to February 2022 were retrospectively analyzed. Among them, 50 patients treated with folic acid were set as the control group (CG), and the remaining 58 patients treated with additional hyperbaric oxygen therapy were in the study group (SG). Clinical efficacy was compared between the two groups after treatment, and changes in Hcy level before and after treatment were observed. Montreal Cognitive Assessment (MoCA) was used to compare the improvement of cognitive function between two groups. According to the efficacy after treatment, patients with markedly effective and effective responses were set as the improved group, and patients with ineffective response as the unimproved group. Risk factors affecting the efficacy of the patients were analyzed by logistic regression. Also, changes in quality of life (assessed by activities of daily living (ADL) scale) before and after treatment as well as the incidence of adverse reactions after treatment were and compared between groups. RESULTS: Before treatment, there was no significant difference identified in MoCA scores, plasma Hcy levels, or ADL scores between the two groups (P > 0.05). After treatment, scores of MoCA and ADL increased and plasma Hcy level decreased in both groups, and the changes in the SG were more significant than those in the CG (P < 0.05). Additionally, no notable difference was observed in the incidence of adverse reactions between the two groups (P > 0.05). Logistic regression analysis revealed that hypertension, hyperlipidemia, and diabetes were risk factors affecting the efficacy. CONCLUSION: Hyperbaric oxygen combined with folic acid can effectively improve cognitive function and quality of life, and reduce Hcy level in patients with CSVD. In addition, hypertension, hyperlipidemia, and diabetes are risk factors affecting efficacy.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".