Bibliographic record
Abstract
On Friday, Jan. 22, at around 3:00 p.m. on the US West Coast, Robert Huizinga celebrated a milestone. He received word that the US Food and Drug Administration had approved voclosporin, a drug developed by Aurinia Pharmaceuticals for the treatment of adults with lupus nephritis. To Huizinga, Aurinia’s executive vice president of research, the FDA approval was the culmination of more than 15 years of work. “It was immensely gratifying,” he recalls. “I will remember that day for the rest of my life.” Voclosporin was discovered in the mid-1990s at Isotechnika Pharma, which merged with the Canadian biotech firm Aurinia in 2013 and took the firm’s name. Huizinga led the clinical development program for voclosporin before and after the acquisition—including a shift in the synthesis from one that yielded racemates to one that yields a single trans isomer. The result was the first FDA-approved oral therapy for lupus nephritis. Now
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.005 | 0.012 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.002 |
| Science and technology studies | 0.012 | 0.003 |
| Scholarly communication | 0.024 | 0.012 |
| Open science | 0.002 | 0.009 |
| Research integrity | 0.007 | 0.010 |
| Insufficient payload (model declined to judge) | 0.389 | 0.306 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".